Evidence map›Paper›PMID 36538276›Full record

Trial reportDigestive diseases and sciences2023

High-Intensity Interval Training is Safe, Feasible and Efficacious in Nonalcoholic Steatohepatitis: A Randomized Controlled Trial.

Shelley E Keating, Ilaria Croci, Matthew P Wallen, Emily R Cox, Moe Thuzar, Uyen Pham, Gregore I Mielke, Jeff S Coombes, Graeme A Macdonald, Ingrid J Hickman

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Digestive diseases and sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 6 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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  17. Exercise improves surrogate measures of liver histological response in metabolic dysfunction-associated steatotic liver disease.Liver international : official journal of the International Association for the Study of the Liver · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Shelley E KeatingCentre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. s.keating@uq.edu.au.ORCID http://orcid.org/0000-0001-5357-2721
Ilaria CrociCentre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia.
Matthew P WallenCaring Futures Institute, College of Nursing and Health Sciences, Flinders University, Adelaide, Australia.
Emily R CoxSchool of Environmental and Life Sciences, University of Newcastle, Ourimbah, Australia.
Moe ThuzarDepartment of Endocrinology & Diabetes, Princess Alexandra Hospital, Brisbane, Australia.
Uyen PhamQueensland Diabetes and Endocrine Centre, Mater Hospital, Brisbane, Australia.
Gregore I MielkeSchool of Public Health, The University of Queensland, Brisbane, Australia.
Jeff S CoombesCentre for Research on Exercise, Physical Activity and Health, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia.
Graeme A MacdonaldFaculty of Medicine, The University of Queensland, Brisbane, Australia.
Ingrid J HickmanFaculty of Medicine, The University of Queensland, Brisbane, Australia.
The University of Queensland · AUFederation University · AUHunter Water · AUQueensland University of Technology · AUTranslational Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHigh-Intensity Interval Training (HIIT) involves bursts of high-intensity exercise interspersed with lower-intensity exercise recovery. HIIT may benefit cardiometabolic health in people with nonalcoholic steatohepatitis (NASH).

aimsWe aimed to examine the safety, feasibility, and efficacy of 12-weeks of supervised HIIT compared with a sham-exercise control (CON) for improving aerobic fitness and peripheral insulin sensitivity in biopsy-proven NASH.

methodsParticipants based in the community [(n = 14, 56 ± 10 years, BMI 39.2 ± 6.7 kg/m

resultsThere were no HIIT-related adverse events and HIIT was globally feasible [program completion 75%, global adherence 100% (including adherence to session 95.4 ± 7.3%, interval intensity 95.3 ± 6.0% and duration 96.8 ± 2.4%)]. A large between-group effect was observed for exercise capacity [mean difference 134.2 s (95% CI 19.8, 248.6 s), ƞ

conclusionsHIIT is safe, feasible and efficacious for improving exercise capacity and peripheral insulin sensitivity in people with NASH. CLINICAL TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trial Registry (anzctr.org.au) identifier ACTRN12616000305426 (09/03/2016).

Indexed as

High-Intensity Interval TrainingInsulin ResistanceNon-alcoholic Fatty Liver DiseaseAustraliaExerciseFemaleHumansMaleExerciseInsulin resistanceLifestyleMetabolic-associated fatty liver diseaseNAFLDNonalcoholic fatty liver disease

Identifiers

PMID36538276
PMCPMC9763796
OpenAlexW4312212028

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.