Evidence map›Paper›PMID 36538173›Full record

ArticleMolecular biology reports2023

Cinnamaldehyde affects lipid droplets metabolism after adipogenic differentiation of C2C12 cells.

Yanrong Liu, Zhengqun Liu, Qiang Luo, Zhuwen Sun, Ning Li, Zi Zheng, Shuqin Mu, Xiaoqiao Zhou, Jun Yan, Chao Sun and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Yanrong LiuInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China.ORCID http://orcid.org/0000-0001-7808-912X
Zhengqun LiuInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China.ORCID http://orcid.org/0000-0002-5846-5498
Qiang LuoInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China.ORCID http://orcid.org/0000-0002-3970-9610
Zhuwen SunInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China.ORCID http://orcid.org/0000-0002-2143-4866
Ning LiInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China.ORCID http://orcid.org/0000-0002-0926-4905
Zi ZhengInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China.ORCID http://orcid.org/0000-0001-6631-2849
Shuqin MuInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China.ORCID http://orcid.org/0000-0001-9657-0320
Xiaoqiao ZhouCollege of Animal Science and Technology, Qingdao Agricultural University, 266109, Qingdao, China.ORCID http://orcid.org/0000-0002-3051-2723
Jun YanInstitute of Animal husbandry and veterinary, Tianjin Academy of Agricultural Science, 300381, Tianjin, China. yjjsxz@163.com.ORCID http://orcid.org/0000-0002-9404-3540
Chao SunCollege of Animal Science and Technology, Northwest A&F University, 712100, Yangling, Shaanxi, China. sunchao2775@163.com.ORCID http://orcid.org/0000-0001-7222-4028
Hongfu ZhangState Key Laboratory of Animal Nutrition, Institute of Animal Science, Chinese Academy of Agricultural Sciences, 100193, Beijing, China.ORCID http://orcid.org/0000-0001-8790-2709
Tianjin Academy of Agricultural Sciences · CNChinese Academy of Agricultural Sciences · CNNorth West Agriculture and Forestry University · CNQingdao Agricultural University · CNShaanxi Science and Technology Department · CN

Funding

Fujian Provincial Key Laboratory for the Development of Bioactive Material from Marine Algae, Quanzhou Normal University Fujian Provincial Key Laboratory for the Development of Bioactive Material from Marine Algae, Quanzhou Normal Universitythe Financial Seed Industry Innovation Research Project of Tianjin Academy of Agricultural Sciences 2022ZYCX009the Livelihood Science and Technology Project of Gansu province 20210306NCC0180The Natural Science Foundation of Tianjin 18JCQNJC15100The Pig Industry Technology System Innovation Team in Tianjin ITTPRS2021005Tianjin Science and Technology Plan Project 19ZXZYSN00120Tianjin Science and Technology Plan Project under Grant 22ZYCGSN00130
6 · The paper itself

Abstract

backgroundBased on our previous research conducted on cinnamaldehyde (CA) exhibiting its ability to improve the growth performance of fattening pigs and the adipogenesis induction model of C2C12 cells constructed in our laboratory, we explored the effects of CA on the generation and development of lipid droplets (LDs) in adipogenic differentiated C2C12 cells. METHODS AND

resultsC2C12 cells were treated with either 0.4 mM or 0.8 mM CA. BODIPY staining and triglyceride measurements were conducted to observe the morphology of LDs, and Western blotting was used to measure the expression of their metabolism-related proteins. The results showed that the average number of LDs in the CA treatment groups was more than the control group (P < 0.05), whereas the average LD size and triglyceride content decreased (P < 0.05). Compared with the control group, the expression levels of fusion-related genes in the LDs of the CA treatment group significantly decreased, while decomposition-related genes and autophagy-related genes in the LDs in C2C12 cells significantly increased (P < 0.01).

conclusionCinnamaldehyde promoted the decomposition and autophagy of lipid droplets in C2C12 cells and inhibited the fusion of lipid droplets.

Indexed as

AcroleinAdipocytesCell DifferentiationLipid DropletsLipid MetabolismAnimalsAutophagyCell LineFood QualityMeatMembrane FusionMiceTriglyceridesAcroleincinnamaldehydeTriglyceridesAdipogenic differentiationC2C12 cellsCinnamaldehydeLipid dropletsMetabolism

Identifiers

PMID36538173
OpenAlexW4312018827

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.