Evidence map›Paper›PMID 36538155›Full record

ArticleJournal of neurology2023

Diagnosis and management of adult primary angiitis of the central nervous system: an international survey on current practices.

Ahmad Nehme, Sylvain Lanthier, Marion Boulanger, Achille Aouba, Patrice Cacoub, David Jayne, Jean-Paul Makhzoum, Christian Pagnoux, Maxime Rhéaume, Benjamin Terrier and 2 more

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In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.8field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 8 institutions in 3 countries.

Ahmad NehmeCaen Normandie University, Caen, France. nehme-a@chu-caen.fr.ORCID http://orcid.org/0000-0002-7700-6799
Sylvain LanthierDepartment of Neurology, Hôpital du Sacré-cœur de Montréal, Université de Montréal, Montréal, Canada.
Marion BoulangerCaen Normandie University, Caen, France.
Achille AoubaCaen Normandie University, Caen, France.
Patrice CacoubDepartment of Internal Medicine and Clinical Immunology, AP-HP, Groupe Hospitalier Pitié-Salpêtrière, 75013, Paris, France.
David JayneDepartment of Medicine, University of Cambridge, Cambridge, UK.
Jean-Paul MakhzoumDepartment of Internal Medicine, Hôpital du Sacré-cœur de Montréal, Université de Montréal, Montréal, Canada.
Christian PagnouxDivision of Rheumatology, Vasculitis Clinic, Mount Sinai Hospital, University of Toronto, Toronto, Canada.
Maxime RhéaumeDepartment of Internal Medicine and Clinical Immunology, Dijon University Hospital, Dijon, France.
Benjamin TerrierDepartment of Internal Medicine, National Referral Center for Rare Systemic Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris, Paris, France.
Emmanuel TouzéCaen Normandie University, Caen, France.
Hubert de BoyssonCaen Normandie University, Caen, France.
Inserm · FRCentre Hospitalier Universitaire de Nice · FRHôpital du Sacré-Cœur de Montréal · CAHôpital Cochin · FRMaison des Sciences sociales et des Humanités de Dijon · FRMount Sinai Hospital · CAUniversité Paris Cité · FRUniversity of Cambridge · GB

Funding

Fonds de Recherche du Québec - Santé 296911
6 · The paper itself

Abstract

backgroundPrimary angiitis of the central nervous system (PACNS) is a rare disease, for which no validated guidelines exist. We report the findings of a survey on the clinical practice of physicians who manage adults with PACNS.

methodsAn online survey was distributed through neurology, internal medicine, and rheumatology societies in Canada and Europe. Participants who were directly involved as treating physicians for at least two adult patients with PACNS were eligible for the survey.

resultsNinety-six physicians completed the survey. Most participants were neurologists (n = 38, 40%), internists (n = 34, 35%) or rheumatologists (n = 22, 23%). Participants obtained a CNS biopsy in a median of 25% (IQR: 5-50%) of suspected PACNS cases. When determining the degree to which eight scenarios justified a CNS biopsy, participants achieved fair inter-rater agreement (Gwet's AC

conclusionThis survey illustrates current real-world management of PACNS and emphasizes several areas for which physicians still lack study-based evidence and/or clinical practice guidelines.

Indexed as

Vasculitis, Central Nervous SystemAdultCyclophosphamideGlucocorticoidsHumansImmunosuppressive AgentsCyclophosphamideGlucocorticoidsImmunosuppressive AgentsCentral nervous system vasculitisManagementPracticePrimary angiitis of the central nervous systemSurvey

Identifiers

PMID36538155
OpenAlexW4312019818

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.