SynthesisAIDS and behavior2023
Substance Use and Adherence to HIV Pre-Exposure Prophylaxis in Studies Enrolling Men Who Have Sex with Men and Transgender Women: A Systematic Review.
Synthesis in AIDS and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pre-exposure Prophylaxis Adherence Among Men Who Have Sex With Men: A Systematic Review and Meta-analysis.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2024Pooled it
- Characterizing the Role of Neighborhood Disadvantage in a Digital PrEP Intervention for Young Sexual and Gender Minority Men.AIDS and behavior · 2026Trial
- Alcohol Use and the Care Continuum for HIV Preexposure Prophylaxis: An Updated Scoping Review of Research and Interventions.AIDS and behavior · 2026Review
- Associations Between Psychosocial Factors and Pre-exposure Prophylaxis (PrEP) Adherence Among Black Men Who Have Sex with Men in Ending the HIV Epidemic Jurisdictions: Findings from Project Adhere.Archives of sexual behavior · 2026Article
- Validation of the Stimulant Use Motives Scale and Assessment of Its Associations with Psychosocial Functioning and Sexual Health in U.S. Men Who Have Sex with Men.Substance use & misuse · 2026Article
- Persistence on Oral HIV Pre-Exposure Prophylaxis Among Key Populations at a Centre in Buenos Aires: A Survival Analysis of a Real-World Cohort.Journal of the International AIDS Society · 2026Article
- Longitudinal Analysis of Substance Use as a Predictor PrEP Use and Adherence Among Young Transgender Women and Nonbinary Individuals.AIDS and behavior · 2026Article
- Barriers and Facilitators to Pre-exposure Prophylaxis Adherence Among Thai Men Who have Sex with Men in Bangkok: COM-B Model Analysis.AIDS and behavior · 2026Article
- Medication adherence and its associated factors among oral pre-exposure prophylaxis (PrEP) users in China: The Real-world E-consumer Cohort of PrEP study.PLoS medicine · 2026Article
- PrEP Intentions, Heavy Substance Use, and Gender Affirmation among Black and Latine Transgender and Gender-Expansive Youth: A Structural Equation Modeling Analysis.AIDS and behavior · 2026Article
- Alcohol and Cannabis co-use and HIV risk, Treatment and Prevention Outcomes: A Scoping Review.Current addiction reports · 2026Article
- Cannabis and Alcohol Co-Use And HIV Biomedical Intervention Engagement Among Black Sexual/Gender Minority People: A Day-Level Analysis.American journal of preventive medicine · 2026Article
- Competence to Consent and Willingness to Participate in Behavioral Trials Among a Mixed HIV Serostatus Sample of Young Gay and Bisexual Men Who Use Stimulants: A Mixed-Methods Study.Substance use & misuse · 2026Article
- Neighborhood Disadvantage, Syndemic Conditions, and PrEP Non-Adherence in Young Sexual and Gender Minority Men.AIDS and behavior · 2025Article
- Intentions to Use PrEP Among a National Sample of Transgender and Gender-Expansive Youth and Emerging Adults: Examining Gender Minority Stress, Substance Use, and Gender Affirmation.AIDS and behavior · 2025Article
- Alcohol Use Disorder Diagnoses Among Individuals Who Take HIV Preexposure Prophylaxis.JAMA network open · 2025Article
- Association between substance use and PrEP adherence among adolescent girls and young women enrolled in an HIV prevention study in Southern Africa.PLOS global public health · 2025Article
- Preferences for Starting Daily, On-Demand, and Long-Acting Injectable HIV Preexposure Prophylaxis Among Men Who Have Sex With Men in the United States (2021-2022): Nationwide Online Cross-Sectional Study.JMIR public health and surveillance · 2024Article
- Pre-exposure prophylaxis (PrEP) among people who use drugs: a qualitative scoping review of implementation determinants and change methods.Addiction science & clinical practice · 2024Article
- Trajectories of Pre-exposure Prophylaxis Adherence Among Commercially Insured Individuals.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Optimal adherence to pre-exposure prophylaxis (PrEP) is critical, but challenging. Men who have sex with men and transgender women have high rates of HIV incidence and substance use. Substance use is associated with reduced adherence to other medications, but associations between substance use and adherence to PrEP are less clear. Thus, the current review 1) systematically evaluates the measurement of substance use and PrEP adherence in studies examining both and 2) summarizes reported findings. Peer-reviewed articles published between 2010 - April 2021 examining associations between substance use and PrEP adherence were reviewed. Fifty studies met inclusion criteria. Assessment of substance use (i.e., mostly via self-reports at baseline) and PrEP adherence (i.e., often via tenofovir diphosphate [TFV-DP] concentration levels at follow-up) varied considerably across studies. Many studies used categorical variables (e.g., substance use: yes/no). Studies using TFV-DP levels defined adherence consistently (i.e., TFV-DP ≥ 700 fmol/punch), with slight variations. Qualitative studies (n = 10) indicated that substance use (mainly alcohol) is related to poorer PrEP adherence. While quantitative findings to date are equivocal for alcohol, there is a pattern of findings linking stimulant use with poorer PrEP adherence. This review reveals four methodological gaps, which can be addressed in future research by: 1) use of uniform benchmarks for substance use measures, 2) prospective assessment for substance use, 3) use of continuous outcome variables wherever possible, and 4) more extensive consideration of potential confounders. Addressing these methodological gaps may help us reach more definitive conclusions regarding associations between substance use and PrEP adherence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.