Evidence map›Paper›PMID 36538125›Full record

ArticleInternational ophthalmology2023

Corneal biomechanical properties in vernal keratoconjunctivitis and its subtypes: a preliminary study.

Xueling Zhang, Feifei Huang, Jini Qiu, Yujing Yang, Chaoran Zhang

Abstract read
PubMed Publisher
In one paragraph

Article in International ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Vernal Keratoconjunctivitis: A Systematic Review.Clinical reviews in allergy & immunology · 2023
    Pooled it
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xueling Zhang *Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, No. 83, Fenyang Road, Xuhui Distinct, Shanghai, 200031, China.ORCID http://orcid.org/0000-0001-5433-9745
Feifei Huang *Department of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, No. 83, Fenyang Road, Xuhui Distinct, Shanghai, 200031, China.
Jini QiuDepartment of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, No. 83, Fenyang Road, Xuhui Distinct, Shanghai, 200031, China.
Yujing YangDepartment of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, No. 83, Fenyang Road, Xuhui Distinct, Shanghai, 200031, China.
Chaoran ZhangDepartment of Ophthalmology, Eye Ear Nose and Throat Hospital of Fudan University, No. 83, Fenyang Road, Xuhui Distinct, Shanghai, 200031, China. zhangchaoran@hotmail.com.ORCID http://orcid.org/0000-0002-7470-011X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo explore the corneal biomechanical properties (CBPs) of patients with vernal keratoconjunctivitis (VKC) and the discrepancies among three subtypes of VKC including palpebral, limbal, and mixed forms.

methodsForty eyes of 20 VKC patients and twenty eyes of ten non-VKC patients were included in this case-control study. Patients with VKC were further divided into three subtypes (six patients in Palpebral form, five patients in limbal form, and nine patients in mixed form). The CBPs of all patients were obtained from the Corneal Visualization Scheimpflug Technology (Corvis ST).

resultsFirst applanation (A1) length, Ambrosio relational thickness in horizontal (ARTh), and stiffness parameter at first applanation (SP-A1) were significantly lower in the VKC group while A1 velocity was significantly higher in the VKC group (p < 0.05), compared to the non-VKC group. Furthermore, A1 velocity presented a positive correlation with disease course (p < 0.05). In addition, VKC patients of limbal form had lower central corneal thickness (CCT), SP-A1, and higher deformation amplitude ratio (DA ratio), compared to the other two subtypes (p < 0.05). Besides, patients in limbal form had higher A1 velocity, integrated radius, and corneal biomechanical index (CBI) compared with mixed form, and lower A1 length than palpebral form (p < 0.05).

conclusionsThe corneas of VKC patients were softer and more protruded compared with the control group, and the property of steepness was closely related to disease course. VKC patients in limbal form were more inclined to be keratoconus than the other two subtypes due to their CBPs` discrepancies.

Indexed as

Conjunctivitis, AllergicKeratoconusBiomechanical PhenomenaCase-Control StudiesCorneaCorneal TopographyDisease ProgressionEyelidsHumansCorneal biomechanical propertiesCorvis STKeratoconusVernal keratoconjunctivitis

Identifiers

PMID36538125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.