Evidence map›Paper›PMID 36538032›Full record

ArticleScience (New York, N.Y.)2023

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.

Danyel Lee, Jérémie Le Pen, Ahmad Yatim, Beihua Dong, Yann Aquino, Masato Ogishi, Rémi Pescarmona, Estelle Talouarn, Darawan Rinchai, Peng Zhang and 94 more

Open access · hybridAbstract read
In one paragraph

Article in Science (New York, N.Y.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
34.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 158 citations in OpenAlex.

  1. Article
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  4. Article
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  8. Article
  9. Review
  10. Article
  11. Article
  12. RNase L Regulates Antiviral Responsiveness through Cleavage of XBP1 mRNA.bioRxiv : the preprint server for biology · 2026
    Article
  13. Article
  14. Review
  15. Intrinsic OASL expression governs heterogeneity in interferon induction during influenza A virus infection.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. iScience · 2025
    Article

46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

104 authors at 20 institutions in 10 countries.

Danyel LeeSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3124-0245
Jérémie Le Pen *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-7025-9526
Ahmad Yatim *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Beihua Dong *Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.
Yann Aquino *Human Evolutionary Genetics Unit, Institut Pasteur, Paris City University, CNRS UMR 2000, Paris, France.ORCID 0000-0001-7669-4721
Masato Ogishi *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-2421-7389
Rémi Pescarmona *Laboratory of Immunology, Lyon Sud Hospital, Lyon, France.ORCID 0000-0002-7218-3294
Estelle Talouarn *Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0002-5016-0446
Darawan Rinchai *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-8851-7730
Peng Zhang *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-6129-567X
Magali Perret *Laboratory of Immunology, Lyon Sud Hospital, Lyon, France.ORCID 0000-0002-9215-5186
Zhiyong LiuSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-6473-348X
Iolanda JordanPediatric Intensive Care Department, Hospital Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0002-2041-4425
Sefika Elmas BozdemirBursa City Hospital, Bursa, Turkey.ORCID 0000-0003-1058-0320
Gulsum Iclal BayhanAnkara City Hospital, Yildirim Beyazit University, Ankara, Turkey.ORCID 0000-0002-1423-4348
Camille BeaufilsImmunology and Rheumatology Division, Department of Pediatrics, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada.ORCID 0000-0002-8630-3509
Lucy BizienLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0001-9163-9122
Aurelie BisiauxHuman Evolutionary Genetics Unit, Institut Pasteur, Paris City University, CNRS UMR 2000, Paris, France.ORCID 0000-0002-2447-3393
Weite LeiSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-1677-8901
Milena HasanCenter for Translational Research, Institut Pasteur, Paris City University, Paris, France.
Jie ChenSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Christina GaughanDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-0869-9026
Abhishek AsthanaDepartment of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0002-5429-6199
Valentina LibriCenter for Translational Research, Institut Pasteur, Paris City University, Paris, France.ORCID 0000-0002-2080-1089
Joseph M LunaLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-2415-9203
Fabrice JaffréDepartment of Surgery, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-4858-1954
H-Heinrich HoffmannLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-0554-0244
Eleftherios MichailidisLaboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-9907-4346
Marion MoreewsInternational Center of Infectiology Research (CIRI), University of Lyon, INSERM U1111, Claude Bernard University, Lyon 1, CNRS, UMR5308, ENS of Lyon, Lyon, France.ORCID 0000-0002-5116-2443
Yoann SeeleuthnerLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.
Kaya BilguvarDepartments of Neurosurgery and Genetics and Yale Center for Genome Analysis, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0002-7313-7652
Shrikant ManeDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0002-3267-5139
Carlos FloresResearch Unit, Nuestra Señora de la Candelaria University Hospital, Santa Cruz de Tenerife, Spain.ORCID 0000-0001-5352-069X
Yu ZhangLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-6904-0372
Andrés A AriasSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-9478-8403
Rasheed BaileySt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Agatha SchlüterNeurometabolic Diseases Laboratory, IDIBELL-Hospital Duran I Reynals, CIBERER U759, ISIiii, Madrid, Spain.ORCID 0000-0001-6732-1528
Baptiste MilisavljevicSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Benedetta BigioSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Tom Le VoyerLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0002-0630-8626
Marie MaternaLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0003-2145-5285
Adrian GervaisLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0002-1083-5787
Marcela Moncada-VelezSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-3073-5345
Francesca PalaLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0003-4537-9061
Tomi LazarovImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0002-6312-0080
Romain LevyLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0002-6393-0198
Anna-Lena NeehusLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0002-8573-6820
Jérémie RosainLaboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM U1163, Paris, France.ORCID 0000-0002-2822-161X
Jessica PeelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Yi-Hao ChanSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-0329-238X
Marie-Paule MorinImmunology and Rheumatology Division, Department of Pediatrics, University of Montreal, CHU Sainte-Justine, Montreal, QC, Canada.
Rosa Maria Pino-RamirezPediatrics Department, Hospital Sant Joan de Déu, Barcelona, Spain.ORCID 0000-0001-9939-7383
Serkan BelkayaDepartment of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey.ORCID 0000-0003-4214-382X
Lazaro LorenzoSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-6648-8684
Jordi AntonDepartment of Surgery and Surgical Specializations, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-8792-4219
Selket DelafontaineDepartment of Pediatrics, University Hospitals Leuven, Leuven, Belgium.ORCID 0000-0002-8985-8155
Julie ToubianaDepartment of General Pediatrics and Pediatric Infectious Diseases, Necker Hospital for Sick Children, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris City University, Paris, France.
Fanny BajolleDepartment of Pediatric Cardiology, Necker Hospital for Sick Children, AP-HP, Paris City University, Paris, France.ORCID 0000-0002-1106-0987
Victoria FumadóKids Corona Platform, Barcelona, Spain.
Marta L DeDiegoDepartment of Molecular and Cellular Biology, National Center for Biotechnology (CNB-CSIC), Madrid, Spain.
Nadhira FidouhLaboratory of Virology, Bichat-Claude Bernard Hospital, Paris, France.
Flore RozenbergLaboratory of Virology, AP-HP, Cochin Hospital, Paris, France.
Jordi Pérez-TurMolecular Genetics Unit, Institute of Biomedicine of Valencia (IBV-CSIC), Valencia, Spain.ORCID 0000-0002-9111-1712
Shuibing ChenDepartment of Surgery, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-6294-5187
Todd EvansDepartment of Surgery, Weill Cornell Medical College, New York, NY, USA.ORCID 0000-0002-7148-9849
Frédéric GeissmannImmunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID 0000-0001-5029-2468
Pierre LebonMedical School, Paris City University, Paris, France.
Susan R WeissDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-8155-4528
Damien BonnetDepartment of Pediatric Cardiology, Necker Hospital for Sick Children, AP-HP, Paris City University, Paris, France.ORCID 0000-0002-8722-5805
Xavier DuvalBichat-Claude Bernard Hospital, Paris, France.
CoV-Contact Cohort§
COVID Human Genetic Effort¶
Qiang Pan-HammarströmDepartment of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.ORCID 0000-0003-1990-8804
Anna M PlanasDepartment of Neuroscience and Experimental Therapeutics, Institute for Biomedical Research of Barcelona (IIBB), Spanish National Research Council (CSIC), Barcelona, Spain.ORCID 0000-0002-6147-1880
Isabelle MeytsDepartment of Pediatrics, University Hospitals Leuven and Laboratory for Inborn Errors of Immunity, KU Leuven, Leuven, Belgium.ORCID 0000-0003-1214-0302
Filomeen HaerynckPrimary Immunodeficiency Research Laboratory, Center for Primary Immunodeficiency Ghent, Ghent University Hospital, Ghent, Belgium.ORCID 0000-0001-9161-7361
Aurora PujolNeurometabolic Diseases Laboratory, IDIBELL-Hospital Duran I Reynals; and Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain.ORCID 0000-0002-9606-0600
Vanessa Sancho-ShimizuDepartment of Paediatric Infectious Diseases and Virology, Imperial College London, London, UK.ORCID 0000-0002-3519-0727
Clifford L DalgardThe American Genome Center, Collaborative Health Initiative Research Program, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID 0000-0003-2025-8239
Jacinta BustamanteSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-3439-2482
Anne PuelSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-2603-0323
Stéphanie Boisson-DupuisSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-7115-116X
Bertrand BoissonSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-5240-3555
Tom ManiatisNew York Genome Center, New York, NY, USA.ORCID 0000-0002-2722-8633
Qian ZhangSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-9040-3289
Paul BastardSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-5926-8437
Luigi NotarangeloLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-8335-0262
Vivien BéziatSt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-4020-824X
Rebeca Perez de DiegoLaboratory of Immunogenetics of Human Diseases, Innate Immunity Group, IdiPAZ Institute for Health Research, La Paz Hospital, Madrid, Spain.ORCID 0000-0001-8426-8765
Carlos Rodriguez-GallegoDepartment of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.
Helen C SuLaboratory of Clinical Immunology and Microbiology, Division of Intramural Research, NIAID, NIH, Bethesda, MD, USA.ORCID 0000-0002-5582-9110
Richard P LiftonDepartment of Genetics, Yale University School of Medicine, New Haven, CT, USA.
Emmanuelle JouanguySt. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-7358-9157
Aurélie Cobat *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-7209-6257
Laia Alsina *Kids Corona Platform, Barcelona, Spain.ORCID 0000-0002-3559-0018
Sevgi Keles *Necmettin Erbakan University, Konya, Turkey.
Elie Haddad *Department of Pediatrics, Department of Microbiology, Immunology and Infectious Diseases, University of Montreal and Immunology and Rheumatology Division, CHU Sainte-Justine, Montreal, QC, Canada.ORCID 0000-0003-2446-6879
Laurent Abel *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-7016-6493
Alexandre Belot *International Center of Infectiology Research (CIRI), University of Lyon, INSERM U1111, Claude Bernard University, Lyon 1, CNRS, UMR5308, ENS of Lyon, Lyon, France.ORCID 0000-0003-4902-5332
Lluis Quintana-Murci *Human Evolutionary Genetics Unit, Institut Pasteur, Paris City University, CNRS UMR 2000, Paris, France.ORCID 0000-0003-2429-6320
Charles M Rice *Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3087-8079
Robert H Silverman *Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.ORCID 0000-0003-2432-992X
Shen-Ying Zhang *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-9449-3672
Jean-Laurent Casanova *St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-7782-4169
Inserm · FRRockefeller University · USUniversité Claude Bernard Lyon 1 · FRInstitut Pasteur · FRHospital Sant Joan de Déu Barcelona · ESHoward Hughes Medical Institute · USCentre National de la Recherche Scientifique · FRConsejo Superior de Investigaciones Científicas · ESCornell University · USKU Leuven · BEYale University · USAnkara Yıldırım Beyazıt University · TRBilkent University · TRCIC Rennes · FRCleveland Clinic Lerner College of Medicine · USHôpital Cochin · FRHospital La Paz Institute for Health Research · ESInstituto de Salud Carlos III · ESKarolinska Institutet · SENational Institute of Allergy and Infectious Diseases · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational SuccessUL1TR001866 · NCATS · ROCKEFELLER UNIVERSITY · PI COLLER, BARRY, KRUEGER, JAMES G · 2016 to 2025
$40.6M
Understanding B cell memory in response to diverse virus infectionsU19AI111825 · NIAID · ROCKEFELLER UNIVERSITY · PI NUSSENZWEIG, MICHEL C · 2014 to 2023
$26.0M
Yale Center for Mendelian GenomicsUM1HG006504 · NHGRI · YALE UNIVERSITY · PI GERSTEIN, MARK BENDER, GUNEL, MURAT · 2016 to 2020
$14.8M
Host factors contributing to susceptibility to COVID-19 diseaseZIAAI001265 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SU, HELEN CHUN-HUI · 2020 to 2025
$9.5M
Monogenic basis of resistance to SARS-CoV2 and predisposition to severe COVID-19R01AI088364 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova, Shen-Ying Zhang · 2010 to 2026
$8.7M
Virology CoreP01AI138938 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2018 to 2022
$8.4M
Control of Viral Pathogenesis by Regulation of 2-5A LevelsR01AI104887 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI SILVERMAN, ROBERT H., WEISS, SUSAN R · 2013 to 2023
$7.6M
Macrophage development and specification in mice.R01AI130345 · NIAID · SLOAN-KETTERING INST CAN RESEARCH · PI Frederic Geissmann · 2017 to 2026
$5.7M
Type I interferon-stimulated genes and the antiviral immune responseR01AI091707 · NIAID · ROCKEFELLER UNIVERSITY · PI RICE, CHARLES M · 2011 to 2020
$5.5M
NHGRI Genome Sequencing Program Coordinating CenterU24HG008956 · NHGRI · RUTGERS, THE STATE UNIV OF N.J. · PI BUYSKE, STEVEN G, MATISE, TARA C. · 2016 to 2020
$4.9M
Human ISG15 and USP18 Deficiencies Underlying Type I InterferonopathiesR01AI127372 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Dusan Bogunovic · 2017 to 2026
$4.7M
Howard Hughes Medical InstituteIntramural NIH HHS ZIA AI001270Medical Research Council MR/S032304/1NCATS NIH HHS UL1 TR001866NCI NIH HHS F99 CA274708NCI NIH HHS P30 CA008748NHGRI NIH HHS U24 HG008956NHGRI NIH HHS UM1 HG006504NIAID NIH HHS P01 AI138938NIAID NIH HHS R01 AI088364NIAID NIH HHS R01 AI091707NIAID NIH HHS R01 AI104887NIAID NIH HHS R01 AI127372NIAID NIH HHS R01 AI130345NIAID NIH HHS R01 AI161444NIAID NIH HHS R21 AI160576NIAID NIH HHS U19 AI111825NIH HHS S10 OD018521
6 · The paper itself

Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a rare and severe condition that follows benign COVID-19. We report autosomal recessive deficiencies of

Indexed as

COVID-19CytokinesEndoribonucleasesSARS-CoV-2Systemic Inflammatory Response Syndrome2',5'-Oligoadenylate SynthetaseAdaptor Proteins, Signal TransducingChildHumansRNA, Double-Stranded2-5A-dependent ribonuclease2',5'-Oligoadenylate SynthetaseAdaptor Proteins, Signal TransducingCytokinesEndoribonucleasesMAVS protein, humanOAS1 protein, humanOAS2 protein, humanRNA, Double-Stranded

Identifiers

PMID36538032
PMCPMC10451000
OpenAlexW4312018826

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.