Evidence map›Paper›PMID 36537902›Full record

ArticleACS nano2023

Fluorous-Directed Assembly of DNA Origami Nanostructures.

Jiajia Zou, Ashley C Stammers, Andrea Taladriz-Sender, Jamie M Withers, Iain Christie, Marina Santana Vega, Badri L Aekbote, William J Peveler, David A Rusling, Glenn A Burley and 1 more

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Hierarchical self-assembly for high-yield addressable complexity at fixed conditions.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  3. Article
  4. Neuromorphic Computing Primitives Using Polymer-Networked Nanoparticles.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024
    Article
  5. Article
  6. DNA Materials Assembled from One DNA Strand.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jiajia ZouJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, United Kingdom.
Ashley C StammersJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, United Kingdom.ORCID 0000-0002-5277-779X
Andrea Taladriz-SenderDepartment of Pure Applied Chemistry, Thomas Graham Building, 295 Cathedral Street, University of Strathclyde, Glasgow G1 1XL, United Kingdom.ORCID 0000-0002-8274-4761
Jamie M WithersJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, United Kingdom.
Iain ChristieJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, United Kingdom.
Marina Santana VegaJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, United Kingdom.ORCID 0000-0002-4143-0379
Badri L AekboteJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, United Kingdom.
William J PevelerSchool of Chemistry, Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, United Kingdom.ORCID 0000-0002-9829-2683
David A RuslingSchool of Pharmacy and Biomedical Sciences, St. Michael's Building, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom.
Glenn A BurleyDepartment of Pure Applied Chemistry, Thomas Graham Building, 295 Cathedral Street, University of Strathclyde, Glasgow G1 1XL, United Kingdom.ORCID 0000-0002-4896-113X
Alasdair W ClarkJames Watt School of Engineering, Advanced Research Centre, University of Glasgow, Glasgow G11 6EW, United Kingdom.ORCID 0000-0001-9797-5776
University of Glasgow · GBUniversity of Strathclyde · GBUniversity of Portsmouth · GB

Funding

Biotechnology and Biological Sciences Research Council BB/T000627/1
6 · The paper itself

Abstract

An orthogonal, noncovalent approach to direct the assembly of higher-order DNA origami nanostructures is described. By incorporating perfluorinated tags into the edges of DNA origami tiles we control their hierarchical assembly via fluorous-directed recognition. When we combine this approach with Watson-Crick base-pairing we form discrete dimeric constructs in significantly higher yield (8x) than when either molecular recognition method is used in isolation. This integrated "catch-and-latch" approach, which combines the strength and mobility of the fluorous effect with the specificity of base-pairing, provides an additional toolset for DNA nanotechnology, one that enables increased assembly efficiency while requiring significantly fewer DNA sequences. As a result, our integration of fluorous-directed assembly into origami systems represents a cheap, atom-efficient means to produce discrete superstructures.

Indexed as

NanostructuresBase PairingDNANanotechnologyNucleic Acid ConformationDNADNA nanotechnologyDNA origamiDNA origami dimerizationfluorousfluorous DNAmolecular recognitionself-assembly

Identifiers

PMID36537902
PMCPMC9835977
OpenAlexW4311992800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.