ArticleRadiology2023
Radiologic and Histologic Correlates of Early Interstitial Lung Changes in Explanted Lungs.
Open access · greenAbstract read
In one paragraph
Article in Radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 19 citations in OpenAlex.
- Automated diagnosis of usual interstitial pneumonia on chest CT via the mean curvature of isophotes.European journal of radiology open · 2026Article
- Interstitial lung abnormality with preserved pulmonary function in lung cancer screening-eligible individuals: long-term effects on function and prognosis.European radiology · 2026Article
- Interstitial lung abnormalities: a mechanistic window into early fibrotic lung disease.Frontiers in medicine · 2026Review
- Cryobiopsy at the dawn of fibrosis: unlocking early diagnosis and therapeutic windows.Frontiers in medicine · 2026Review
- Differentiating clinically important interstitial lung abnormalities in lung cancer screening.BMJ open respiratory research · 2025Article
- Mapping the arterial vascular network in an intact human kidney using hierarchical phase-contrast tomography.Npj imaging · 2025Article
- The association of symptoms, pulmonary function test and computed tomography in interstitial lung disease at the onset of connective tissue disease: an observational study with artificial intelligence analysis of high-resolution computed tomography.Rheumatology international · 2025Observational
- A Comprehensive Review of Interstitial Lung Abnormalities.Respirology (Carlton, Vic.) · 2025Review
- Prediction of pulmonary function decline in fibrous interstitial lung abnormalities based on quantitative chest CT parameters.BMC medical imaging · 2025Article
- Pulmonary diffusing capacity for carbon monoxide and nitric oxide after COVID-19: A prospective cohort study (the SECURe study).Experimental physiology · 2024Article
- Longitudinal assessment of interstitial lung abnormalities on CT in patients with COPD using artificial intelligence-based segmentation: a prospective observational study.BMC pulmonary medicine · 2024Observational
Corrections and comments
- Commented on by
Authors and funding
19 authors at 5 institutions in 6 countries.
Stijn E VerledenFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0002-9656-5844
Arno VanstapelFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).
Joseph JacobFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0002-8054-2293
Tinne GoosFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0002-8081-333X
Jeroen HendriksFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0001-9145-3643
Laurens J CeulemansFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).
Dirk E Van RaemdonckFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0003-1261-0992
Laurens De SadeleerFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).
Robin VosFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).
Johanna M Kwakkel-van ErpFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0002-7558-1239
Arne P NeyrinckFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0001-9930-8045
Geert M VerledenFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0003-3048-2429
Matthieu N BooneFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0002-5478-4141
Wim JanssensFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0003-1830-2982
Els WautersFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0002-0115-0030
Birgit WeynandFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0003-4246-6303
Danny D JonigkFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0002-5251-2281
Johny VerschakelenFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0001-9573-9614
Wim A WuytsFrom the Department of Chronic Diseases and Metabolism, BREATHE (S.E.V., A.V., T.G., L.J.C., D.E.V.R., L.D.S., R.V., G.M.V., W.J., E.W., W.A.W.), Department of Cardiovascular Sciences (A.P.N.), and Department of Imaging and Pathology (B.W., J.V.), KU Leuven, Herestraat 49, 3000 Leuven, Belgium; Department of ASTARC, University of Antwerp, Antwerp, Belgium (S.E.V., J.H.); Department of Respiratory Medicine (S.E.V., J.M.K.v.E.) and Department of Thoracic and Vascular Surgery (S.E.V., J.H.), University Hospital Antwerp, Antwerp, Belgium; Department of Respiratory Medicine (J.J.) and Centre for Medical Image Computing (J.J.), University College London, London, UK; Department of Thoracic Surgery, University Hospital Leuven, Leuven, Belgium (L.J.C., D.E.V.R.); Department of Physics and Astronomy, Ghent University, Ghent, Belgium (M.N.B.); Institute of Pathology, Hannover Medical School, Hannover, Germany (D.D.J.); and Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), Member of the German Center for Lung Research (DZL), Hannover, Germany (D.D.J.).ORCID 0000-0001-9648-3497
University College London · GBUniversity of Antwerp · BEAntwerp University Hospital · BEGhent University · BEMedizinische Hochschule Hannover · DE
Funding
Wellcome Trust 209553Wellcome Trust 209553/Z/17/Z
Abstract
Background Interstitial lung abnormalities (ILAs) reflect imaging features on lung CT scans that are compatible with (early) interstitial lung disease. Despite accumulating evidence regarding the incidence, risk factors, and prognosis of ILAs, the histopathologic correlates of ILAs remain elusive. Purpose To determine the correlation between radiologic and histopathologic findings in CT-defined ILAs in human lung explants. Materials and Methods Explanted lungs or lobes from participants with radiologically documented ILAs were prospectively collected from 2010 to 2021. These specimens were air-inflated, frozen, and scanned with CT and micro-CT (spatial resolution of 0.7 mm and 90 μm, respectively). Subsequently, the lungs were cut and sampled with core biopsies. At least five samples per lung underwent micro-CT and subsequent histopathologic assessment with semiquantitative remodeling scorings. Based on area-specific radiologic scoring, the association between radiologic and histopathologic findings was assessed. Results Eight lung explants from six donors (median age at explantation, 71 years [range, 60-83 years]; four men) were included (unused donor lungs,
Indexed as
BronchiectasisLung Diseases, InterstitialAgedAged, 80 and overFibrosisHumansLungMaleMiddle AgedX-Ray Microtomography
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.