ArticleJournal of extracellular vesicles2022
TGFβ
Open access · goldAbstract read
In one paragraph
Article in Journal of extracellular vesicles, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 47 citations in OpenAlex.
- Plasma-Derived sEVs from HNSCC Patients Differentially Regulate NF-κB Signaling in Macrophages Depending on the HPV Status.Cancers · 2026Article
- Extracellular Vesicles in Head and Neck Cancer-A Systematic Review.Journal of extracellular biology · 2026Review
- Malignant cell-secreted chemokines drive colorectal cancer progression through endothelial cell activation.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Extracellular Vesicle-Mediated Delivery of Curcumin Suppresses Tumor Progression in Murine Oral Squamous Cell Carcinoma.Cancers · 2026Article
- Gsα deficiency in macrophages promotes tumor progression via the MAPK signaling pathway.Journal of molecular medicine (Berlin, Germany) · 2026Article
- Targeting Tumor-Associated Macrophages to Reshape the Immuno-Mechanical Landscape: Molecular Mechanisms and Therapeutic Strategies.International journal of biological sciences · 2026Review
- HMGA1 Activates FGFBP1 Transcription to Enhance Angiogenesis Induction and Tumor Progression via FGF2/FGFR1 Pathway.International journal of biological sciences · 2026Article
- Single-cell identification of an endothelial cell proximal SPP1Scientific reports · 2025Article
- Advances of extracellular vesicles isolation and detection frontier technology: from heterogeneity analysis to clinical application.Journal of nanobiotechnology · 2025Review
- TGF-β-Enriched Exosomes from Acute Myeloid Leukemia Activate Smad2/3-MMP2 and ERK1/2 Signaling to Promote Leukemic Cell Proliferation, Migration, and Immune Modulation.Current issues in molecular biology · 2025Article
- Article
- The role of plasma-derived small extracellular vesicles in pre-metastatic niche formation through modulation of macrophages in head and neck squamous cell carcinoma.British journal of cancer · 2025Article
- Transfer of Oncologic Signals from Melanoma Cells to Benign Melanocytes by Circulating Tumor-Derived Extracellular Vesicles.The Journal of investigative dermatology · 2025Article
- Expression of vesiculation-related genes is associated with a tumor-promoting microenvironment: a pan-cancer analysis.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025Article
- The Role of Extracellular Vesicles in the Control of Vascular Checkpoints for Cancer Metastasis.Cancers · 2025Review
- Exosomes derived from M2 macrophage promote HUVECs proliferation, migration and tube formation in vitro.Scientific reports · 2025Article
- Decoding the Tumor Microenvironment: Exosome-Mediated Macrophage Polarization and Therapeutic Frontiers.International journal of biological sciences · 2025Review
- Exosomes and immune modulation: implications for neuroblastoma immunotherapy.Frontiers in immunology · 2025Review
- Role of exosomes in transforming growth factor-β-mediated cancer cell plasticity and drug resistance.Exploration of targeted anti-tumor therapy · 2025Review
- Extracellular vesicles in cancers: mechanisms, biomarkers, and therapeutic strategies.MedComm · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 8 institutions in 5 countries.
Nils LudwigDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.ORCID https://orcid.org/0000-0001-5561-2184
Saigopalakrishna S YerneniDepartment of Chemical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Juliana H AzambujaDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Monika PietrowskaMaria Sklodowska-Curie National Research Institute of Oncology, Gliwice Branch, Gliwice, Poland.
Piotr WidłakMedical University of Gdańsk, Gdańsk, Poland.
Cynthia S HinckDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Alicja GłuszkoChair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland.
Mirosław J SzczepańskiChair and Department of Biochemistry, Medical University of Warsaw, Warsaw, Poland.
Teresa KärmerDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Isabella KallingerDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Daniela SchulzDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Richard J BauerDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Gerrit SpanierDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Steffen SpoerlDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Johannes K MeierDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Tobias EttlDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Beatrice M RazzoAbramson Cancer Center, University of Pennsylvania, Philadelphia, USA.
Torsten E ReichertDepartment of Oral and Maxillofacial Surgery, University Hospital Regensburg, Regensburg, Germany.
Andrew P HinckDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Theresa L WhitesideDepartment of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID https://orcid.org/0000-0001-7316-6181
University Hospital Regensburg · DEUniversity of Pittsburgh · USMedical University of Warsaw · PLCarnegie Mellon University · USGdańsk Medical University · PLNational Institute of Oncology · HUUniversidade Federal de Ciências da Saúde de Porto Alegre · BRUPMC Hillman Cancer Center · US
Funding
CANCER RESEARCH TRAINING PROGRAMT32CA009615 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Gregory L Beatty, MICHAEL D HOGARTY · 1988 to 2026
$10.4MDepleting exosomes to improve responses to immune therapy in HNSCCU01DE029759 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2020 to 2024
$3.5MSmall extracellular vesicles as biomarkers of prognosis and response to therapy in head and neck cancerR01DE031299 · NIDCR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Brenda B. Diergaarde, Theresa L. Whiteside · 2023 to 2026
$2.9MThe Adenosinergic Pathway in Tumor-derived ExosomesR01CA256068 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JACKSON, EDWIN KERRY, WHITESIDE, THERESA L. · 2021 to 2025
$2.5MRestoring anti-tumor immunity in the microenvironment of head and neck cancerR01CA168628 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WHITESIDE, THERESA L. · 2013 to 2017
$1.7MNCI NIH HHS R01 CA168628NCI NIH HHS R01 CA256068NCI NIH HHS T32 CA009615NIDCR NIH HHS R01 DE031299NIDCR NIH HHS U01 DE029759NIH HHS R01-CA 168628NIH HHS U01-DE-029759
Abstract
Transforming growth factor β (TGFβ) is a major component of tumor-derived small extracellular vesicles (TEX) in cancer patients. Mechanisms utilized by TGFβ
Indexed as
Extracellular VesiclesHead and Neck NeoplasmsAnimalsHumansMacrophagesMiceNeovascularization, PathologicPhenotypeSquamous Cell Carcinoma of Head and NeckTransforming Growth Factor betaTumor MicroenvironmentTransforming Growth Factor betaangiogenesisexosomeshead and neck squamous cell carcinomamacrophagessmall extracellular vesiclesTGFβ
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What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.