SynthesisCirculation2023
Prospective Association of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis.
Synthesis in Circulation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 2 syntheses or guidelines pooled it, 101 citations in OpenAlex.
- Daily Step Count and Depression in Adults: A Systematic Review and Meta-Analysis.JAMA network open · 2024Pooled it
- Pooled it
- Physical activity is associated with exercise capacity among patients undergoing chemotherapy: A pilot randomized controlled trial.PloS one · 2025Trial
- Assessing Electronic Health Record-Derived Outcomes in a Pragmatic Weight Gain Prevention Trial: Effects, Variability, and Implications for Future Trials.The Journal of cardiovascular nursingTrial
- Daily Step Count Is Associated with Frailty Status in Veterans Presenting for Major Operations.Geriatrics (Basel, Switzerland) · 2026Article
- Association between PMBMC cardiovascular disorders · 2026Article
- Self-Reported Habitual Daily Physical Activity as an Independent Predictor of Coronary Artery Disease Extension in Patients with Myocardial Infarction: A Prospective Observational Study.Journal of clinical medicine · 2026Article
- Physical and Lifestyle Predictors of Vascular Health in Premenopausal East Asian Women: The Women's Vascular Health Project.Diseases (Basel, Switzerland) · 2026Article
- Article
- Limitations of Daily Step Count for Assessing Health in Older Adults: The Need to Consider Walking Intensity.Epidemiologia (Basel, Switzerland) · 2026Article
- Joint associations of device-measured step count and sleep duration with incident major adverse cardiovascular events: prospective analysis of the UK Biobank.EClinicalMedicine · 2026Article
- Association between frequency of meeting daily step thresholds and all-cause mortality and cardiovascular disease in older women.British journal of sports medicine · 2025Article
- Bidirectional associations between sleep and physical activity investigated using large-scale objective monitoring data.Communications medicine · 2025Article
- Digital assessment of real-world walking in people with impaired mobility: How many hours and days are needed?The international journal of behavioral nutrition and physical activity · 2025Article
- Step-Determined Physical Activity among Individuals with Chronic Conditions: The 2007-2019 National Health and Nutrition Survey of Japan.JMA journal · 2025Article
- Pediatric heart failure: Current approach and treatment.JHLT open · 2025Article
- Daily steps, cardiorespiratory fitness, and remnant cholesterol in schoolchildren: mediation effects for cardiovascular prevention.Pediatric research · 2025Article
- Prevalence of Meeting Daily Step Count Recommendations in Cardiovascular Patients With and Without Metabolic Syndrome.American journal of medicine open · 2025Article
- Daily Heart Rate per Step: A Wearables Metric Associated With Cardiovascular Disease in a Cross-Sectional Study of theJournal of the American Heart Association · 2025Observational
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
32 authors at 18 institutions in 4 countries.
Funding
Abstract
backgroundTaking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose-response relationship between steps per day and CVD can help inform clinical and public health guidelines.
methodsEight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional hazards regression analyses were completed using study-specific quartiles and hazard ratios (HR) and 95% CI were meta-analyzed with inverse-variance-weighted random effects models.
resultsThe mean age of participants was 63.2±12.4 years and 52% were women. The mean follow-up was 6.2 years (123 209 person-years), with a total of 1523 CVD events (12.4 per 1000 participant-years) reported. There was a significant difference in the association of steps per day and CVD between older (ie, ≥60 years of age) and younger adults (ie, <60 years of age). For older adults, the HR for quartile 2 was 0.80 (95% CI, 0.69 to 0.93), 0.62 for quartile 3 (95% CI, 0.52 to 0.74), and 0.51 for quartile 4 (95% CI, 0.41 to 0.63) compared with the lowest quartile. For younger adults, the HR for quartile 2 was 0.79 (95% CI, 0.46 to 1.35), 0.90 for quartile 3 (95% CI, 0.64 to 1.25), and 0.95 for quartile 4 (95% CI, 0.61 to 1.48) compared with the lowest quartile. Restricted cubic splines demonstrated a nonlinear association whereby more steps were associated with decreased risk of CVD among older adults.
conclusionsFor older adults, taking more daily steps was associated with a progressively decreased risk of CVD. Monitoring and promoting steps per day is a simple metric for clinician-patient communication and population health to reduce the risk of CVD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.