Evidence map›Paper›PMID 36537034›Full record

ArticleJournal of Korean Neurosurgical Society2023

Characteristics of Focused Ultrasound Mediated Blood-Brain Barrier Opening in Magnetic Resonance Images.

Kyung Won Chang, Seung Woo Hong, Won Seok Chang, Hyun Ho Jung, Jin Woo Chang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Korean Neurosurgical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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  7. Editors' Pick in March 2023.Journal of Korean Neurosurgical Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Kyung Won ChangBrain Research Institute, Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Seung Woo HongBrain Research Institute, Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Won Seok ChangBrain Research Institute, Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Hyun Ho JungBrain Research Institute, Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Jin Woo ChangBrain Research Institute, Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea.
Yonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe blood-brain barrier (BBB) is an obstacle for molecules to pass through from blood to the brain. Focused ultrasound is a new method which temporarily opens the BBB, which makes pharmaceutical delivery or removal of neurodegenerative proteins possible. This study was demonstrated to review our BBB opening procedure with magnetic resonance guided images and find specific patterns in the BBB opening.

methodsIn this study, we reviewed the procedures and results of two clinical studies on BBB opening using focused ultrasound regarding its safety and clinical efficacy. Magnetic resonance images were also reviewed to discover any specific findings.

resultsTwo clinical trials showed clinical benefits. All clinical trials demonstrated safe BBB opening, with no specific side effects. Magnetic resonance imaging showed temporary T1 contrast enhancement in the sonication area, verifying the BBB opening. Several low-signal intensity spots were observed in the T2 susceptibility-weighted angiography images, which were also reversible and temporary. Although these spots can be considered as microbleeding, evidence suggests these are not ordinary microbleeding but an indicator for adequate BBB opening.

conclusionMagnetic resonance images proved safe and efficient BBB opening in humans, using focused ultrasound.

Indexed as

Alzheimer’s diseaseBlood brain barrierDrug deliveryFocused ultrasoundGlioblastoma

Identifiers

PMID36537034
PMCPMC10009247
OpenAlexW4312018501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.