Synthesis of Poly(2-(methylsulfinyl)ethyl methacrylate) via Oxidation of Poly(2-(methylthio)ethyl methacrylate): Evaluation of the Sulfoxide Side Chain on Cryopreservation.

Toru Ishibe, Natalia Gonzalez-Martinez, Panagiotis G Georgiou, Kathryn A Murray, Matthew I Gibson

Open access · goldAbstract read

In one paragraph

Article in ACS polymers Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

0.9field-weighted citation impact, top 30% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Toru IshibeDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, U.K.

Natalia Gonzalez-MartinezDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, U.K.ORCID https://orcid.org/0000-0003-1038-5306

Panagiotis G GeorgiouDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, U.K.ORCID https://orcid.org/0000-0001-8968-1057

Kathryn A MurrayDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, U.K.ORCID https://orcid.org/0000-0002-8465-7143

Matthew I GibsonDepartment of Chemistry, University of Warwick, Gibbet Hill Road, CV4 7AL, Coventry, U.K.ORCID https://orcid.org/0000-0002-8297-1278

University of Warwick · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional cryopreservation solutions rely on the addition of organic solvents such as DMSO or glycerol, but these do not give full recovery for all cell types, and innovative cryoprotectants may address damage pathways which these solvents do not protect against. Macromolecular cryoprotectants are emerging, but there is a need to understand their structure-property relationships and mechanisms of action. Here we synthesized and investigated the cryoprotective behavior of sulfoxide (i.e., "DMSO-like") side-chain polymers, which have been reported to be cryoprotective using poly(ethylene glycol)-based polymers. We also wanted to determine if the polarized sulfoxide bond (S

Identifiers

PMID36536886

DOI10.1021/acspolymersau.2c00028

PMCPMC9756334

OpenAlexW4295163511

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.