ArticleBrain, behavior, & immunity - health2022
The gut microbiota, HPA axis, and brain in adolescent-onset depression: Probiotics as a novel treatment.
Article in Brain, behavior, & immunity - health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Probiotic intake and mental health in healthy working adults: a systematic review and meta-analysis of randomized controlled trials.BMC psychology · 2026Pooled it
- The Role of the Gut Microbiota in Anorexia Nervosa in Children and Adults-Systematic Review.International journal of molecular sciences · 2023Pooled it
- Strain-resolved metabolomic chemotyping identifies tryptophan and γ-glutamyl peptides as MGO-AGEs breaking postbiotic compounds for carbonyl stress mitigation.Gut microbes · 2026Article
- Sex and stress paradigm influence behavioural, neuroimmune, and microbiome responses in pubertal CD-1 mice.Brain, behavior, & immunity - health · 2026Article
- The Adolescent Microbiome-Gut-Brain Axis: Development, Mechanisms, and Translational Perspectives.Nutrients · 2026Review
- Exosomes in depression: mechanistic insights, diagnostic potential, and therapeutic opportunities.Molecular psychiatry · 2026Review
- The Interactions Between Circadian Rhythm, Gut Microbiota, and Anxiety: From Mechanisms to Intervention Strategies.Nutrients · 2026Review
- Gut microbiota dysbiosis drives depression-like behavior in adolescent rats via lysine-regulated mTOR autophagy pathway.Translational psychiatry · 2026Article
- Gut microbiota dysbiosis in adolescent depression: a comparative analysis with adult depression and healthy adolescent.Frontiers in microbiology · 2026Article
- Anxiety and depression in emerging adults: The STAND program as a model of scalable screening and intervention.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- The Addition of Marigold Extract to the Diet Improved the Performance of Laying Hens in the Late Laying Period by Increasing Their Antioxidant Capacity, Lipid Metabolism, and Microbial Composition.Antioxidants (Basel, Switzerland) · 2025Article
- Current Insight into Biological Markers of Depressive Disorder in Children and Adolescents: A Narrative Review.Antioxidants (Basel, Switzerland) · 2025Review
- Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis.Molecular medicine (Cambridge, Mass.) · 2025Review
- Post-stroke depression: exploring gut microbiota-mediated barrier dysfunction through immune regulation.Frontiers in immunology · 2025Review
- Genistein improves depression-like behavior in rats by regulating intestinal flora and altering glutamate gene expression.Current research in food science · 2025Article
- Does isovaleric acid play a key role in the interaction between probiotics and antidepressants? A secondary analysis of a randomized clinical trial.Computational and structural biotechnology journal · 2025Article
- Associations of infectious disease-specific, electronic, and general health literacy among high school students with prevalent health challenges: a cross-sectional study.Frontiers in public health · 2025Article
- The role of probiotics in modulation of the gut-brain axis: a prospective therapy for depression and mood disorders.Frontiers in pharmacology · 2025Review
- Gut-brain axis in adolescent depression: a systematic review of psychological implications and behavioral interventions.Frontiers in nutrition · 2025Review
- Probiotics in Traumatic Brain Injury: New Insights into Mechanisms and Future Perspectives.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Stress-associated disruptions in the development of frontolimbic regions may play a critical role in the emergence of adolescent-onset depression. These regions are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA axis is hyperactive in adolescent depression, and interventions that attenuate such hyperactivity hold promise as potential treatments. The Microbiome-Gut-Brain (MGB) axis is an important pathway through which stress dysregulates HPA-axis activity and thus exerts deleterious effects on the adolescent brain. Probiotic agents, which alter the gut microbiota composition by introducing bacterial strains with beneficial physiological effects, normalize aberrant HPA-axis activity and reduce depressive symptoms in both animal studies and adult clinical trials. While the potential utility of such agents in treating or preventing adolescent depression remains largely unexplored, recent data suggest the existence of an adolescent sensitive window during which probiotics may be especially efficacious in reducing depressive symptoms compared to effects observed in adult populations. In this review, we outline evidence that probiotic use may attenuate stress effects on frontolimbic development, providing a novel means of improving depressive symptoms among adolescent populations.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.