ArticleBiology of sex differences2022
High pulse pressure is associated with an increased risk of diabetes in females but not in males: a retrospective cohort study.
Article in Biology of sex differences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Pulse pressure and cardiometabolic disease progression: associations with incident multimorbidity and mortality in UK biobank.Frontiers in cardiovascular medicine · 2026Article
- Control of Pulse Pressure and Factors Affecting it among the Geriatric Population Suffering from Hypertension within the Community.Reviews in cardiovascular medicine · 2025Article
- Article
- Brachial-Ankle Pulse Wave Velocity as a Predictor of Diabetes Development: Elevated Risk Within Normal Range Values in a Low-Risk Population.Journal of the American Heart Association · 2024Article
- The joint effect of cumulative metabolic parameters on the risk of type 2 diabetes: a population-based cohort study.Nutrition & metabolism · 2024Article
- Relationship between Pulse Pressure and Handgrip Strength in the Korean Population: A Nationwide Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Non-linear relationship between pulse pressure and the risk of prediabetes: a 5-year cohort study in Chinese adults.Scientific reports · 2024Article
- A study of the relationship between brachial artery vasodilation and platelet/lymphocyte ratio in diabetic patients with coronary atherosclerosis.Journal of clinical laboratory analysis · 2023Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveAccumulating evidence suggests a close relationship between metabolic disturbance and increased arterial stiffness. However, whether there is an association between pulse pressure (PP) and diabetes and how this association might be impacted by sex is not clear.
methodsA total of 209,635 adult Chinese individuals > 20 years old across 32 sites and 11 cities in China (Shanghai, Beijing, Nanjing, Suzhou, Shenzhen, Changzhou, Chengdu, Guangzhou, Hefei, Wuhan, Nantong) were included in the study; participants were free of diabetes at baseline. In the present study, we analyzed the relationship between PP at baseline and incident diabetes using the Cox proportional hazard model.
resultsDuring a median follow-up of 2.99 years, a total of 3971 participants (2885 men and 1086 women) developed diabetes, and the incidence was 6.3 per 1000 person-years. With each 10 mmHg increase in PP, the multivariable adjusted hazard ratio (HR) (95% confidence interval) for incident diabetes was 1.117 (1.061, 1.176) in females and 0.981 (0.951, 1.012) in males. Using the lowest quartile of PP as the reference category, the hazard ratio (HR) (95% CI) of the highest quartile of PP for incident diabetes was 1.494 (1.225, 1.822) in females and 0.939 (0.843, 1.045) in males. Smooth plots revealed a significant difference between males and females in the HRs for new-onset diabetes according to PP.
conclusionHigher PP was related to future diabetes development in females but not in males and further research is needed to explore the mechanism.
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