Evidence map›Paper›PMID 36536397›Full record

ArticleLipids in health and disease2022

Serum lipid profile in relation to free thyroxine and the effect of levothyroxine treatment on lipids in patients with isolated hypothyroxinemia during pregnancy: a single-center retrospective study.

Yunyi Xu, Yiqi Zhao, Xiaoqin Xu, Qiqi Yan, Liwei Yang

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Lipids in health and disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06527859 (Correlation Between Different Doses of Levothyroxine Supplementation and Peripheral Blood Th17/Treg Balance in Pregnant Women With Normal-high TSH and Positive TPOAb in the First Half of Pregnancy), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06527859 terminatednot on this map

Correlation Between Different Doses of Levothyroxine Supplementation and Peripheral Blood Th17/Treg Balance in Pregnant Women With Normal-high TSH and Positive TPOAb in the First Half of Pregnancy

TypeobservationalSponsorThird Affiliated Hospital of Zhengzhou UniversityRan2022 to 2024Enrolled64ConditionsPregnancy Related, Thyroid Stimulating, Hormone, CArmsLevothyroxin
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Yunyi XuDepartment of Obstetrics and Gynecology, The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Yiqi ZhaoCenter for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Xiaoqin XuDepartment of Gynecology & Obstetrics, Hangzhou Fuyang Women and Children Hospital, Hangzhou, Zhejiang, China.
Qiqi YanDepartment of Obstetrics and Gynecology, The Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China.
Liwei YangCenter for Reproductive Medicine, Department of Obstetrics, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China. yanglw1967@163.com.
Zhejiang Provincial People's Hospital · CNHangzhou Medical College · CNHangzhou Women’s Hospital · CNZhejiang Chinese Medical University · CN

Funding

the Zhejiang Provincial Natural Science Foundation of China LGF19H040013
6 · The paper itself

Abstract

backgroundThyroid function is widely considered a lipid metabolism regulator. However, studies on lipid metabolism in pregnant women with low free thyroxine (FT

methodsThis retrospective study included 164 patients with isolated hypothyroidism (IH) (FT

resultsCompared with the control group, Patients with IH had a higher degree of dyslipidemia, reflected in elevated total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein B (Apo B) levels. In IH patients, an inverse correlation was found between FT

conclusionsLow FT

Indexed as

HypothyroidismThyroxineCholesterol, LDLFemaleHumansLipidsPregnancyRetrospective StudiesThyroid HormonesThyrotropinCholesterol, LDLLipidsThyroid HormonesThyrotropinThyroxineBody mass indexFree thyroxineIsolated hypothyroidismLevothyroxine treatmentPregnancySerum lipid profile

Identifiers

PMID36536397
PMCPMC9761940
OpenAlexW4312114367

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.