Evidence map›Paper›PMID 36536372›Full record

ArticleClinical epigenetics2022

Decreased SUV39H1 at the promoter region leads to increased CREMα and accelerates autoimmune response in CD4

Shuangyan Luo, Huilin Zhang, Yuming Xie, Junke Huang, Danhong Luo, Qing Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Methylation of T and B Lymphocytes in Autoimmune Rheumatic Diseases.Clinical reviews in allergy & immunology · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Shuangyan LuoHunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital, Central South University, #139 Renmin Middle Rd, Changsha, 410011, Hunan, People's Republic of China.
Huilin ZhangClinical Nursing Teaching and Research Section, The Second Xiangya Hospital, Central South University, #139 Renmin Middle Rd, Changsha, 410011, Hunan, People's Republic of China.
Yuming XieHunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital, Central South University, #139 Renmin Middle Rd, Changsha, 410011, Hunan, People's Republic of China.
Junke HuangHunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital, Central South University, #139 Renmin Middle Rd, Changsha, 410011, Hunan, People's Republic of China.
Danhong LuoDepartment of Dermatology, The Fifth People's Hospital of Hainan Province, #49 Longkun South Rd, Haikou, 570206, Hainan, People's Republic of China.
Qing ZhangHunan Key Laboratory of Medical Epigenomics, Department of Dermatology, The Second Xiangya Hospital, Central South University, #139 Renmin Middle Rd, Changsha, 410011, Hunan, People's Republic of China. zhangqing3135@csu.edu.cn.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOverproduction of cAMP-responsive element modulator α (CREMα) in total T cells from patients with systemic lupus erythematosus (SLE) can inhibit IL-2 and increase IL-17A. These ultimately promote progression of SLE. This study aims to investigate the expression of CREMα in SLE CD4

resultsCREMα mRNA was overexpressed in CD4

conclusionsDecreased SUV39H1 in the CREMα promoter region of CD4

Indexed as

Cyclic AMP Response Element ModulatorHistonesLupus Erythematosus, SystemicMethyltransferasesRepressor ProteinsAutoimmunityCD4-Positive T-LymphocytesDNA MethylationDNA Methyltransferase 3AHumansInterleukin-17Interleukin-2LysinePromoter Regions, GeneticT-LymphocytesCREM protein, humanCyclic AMP Response Element ModulatorDNA Methyltransferase 3AHistonesInterleukin-17Interleukin-2LysineMethyltransferasesRepressor ProteinsSUV39H1 protein, humanCREMαDNA methylationDNMT3aH3K4me3H3K9me3Set1SUV39H1Systemic lupus erythematosus

Identifiers

PMID36536372
PMCPMC9764740
OpenAlexW4311936193

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.