Evidence map›Paper›PMID 36536319›Full record

ArticleBMC ophthalmology2022

Vitreous inflammatory and angiogenic factors on patients with proliferative diabetic retinopathy or diabetic macular edema: the role of Lipocalin2.

Georgios Batsos, Eleni Christodoulou, Evita Evangelia Christou, Petros Galanis, Andreas Katsanos, Loren Limberis, Maria Stefaniotou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Georgios BatsosFaculty of Medicine, Department of Ophthalmology, University of Ioannina, 45110, Ioannina, Greece.
Eleni ChristodoulouFaculty of Medicine, Department of Ophthalmology, University of Ioannina, 45110, Ioannina, Greece.
Evita Evangelia ChristouFaculty of Medicine, Department of Ophthalmology, University of Ioannina, 45110, Ioannina, Greece. evitachristou@gmail.com.ORCID http://orcid.org/0000-0002-7959-4854
Petros GalanisClinical Epidemiology Laboratory, National and Kapodistrian University of Athens, Athens, Greece.
Andreas KatsanosFaculty of Medicine, Department of Ophthalmology, University of Ioannina, 45110, Ioannina, Greece.
Loren LimberisDepartment of Engineering, East Carolina University, Greenville, NC, USA.
Maria StefaniotouFaculty of Medicine, Department of Ophthalmology, University of Ioannina, 45110, Ioannina, Greece.
University of Ioannina · GREast Carolina University · USNational and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeQuantitative analysis of vitreous inflammatory and angiogenic factors from patients with proliferative diabetic retinopathy (PDR) or diabetic macular edema (DME). MATERIALS AND

methodsCollection of undiluted vitreous samples from 20 diabetic patients: 13 with proliferative diabetic retinopathy (PDR) and 7 with diabetic macular edema (DME). DME patients had suboptimal response to anti-VEGF treatment. Samples from 11 control patients, with vitreomacular interface pathology such as idiopathic epiretinal membrane (iERM) (n = 4), vitreomacular traction syndrome (VMT) (n = 3) and full thickness macular hole (FTMH) (n = 3), were also collected. The levels of IL1b, IL6, IL8, IL27, TNFα, ICAM-1, VCAM, MCP-1, VEGFA and LCN2 were measured using cytometry flow analysis. Median values were compared with Mann-Whitney test since the distributions were skewed. Statistical analysis was performed with the Statistical Package for Social Sciences software (IBM Corp. Released 2012. IBM SPSS Statistics for Windows, Version 21.0. Armonk, NY: IBM Corp.).

resultsThe median concentration of LCN2, IL6, IL8, IL1b, IL27, ICAM, VCAM-1, MCP-1, TNFa and VEGFA was higher in PDR patients than in controls. Similarly, the median concentration of LCN2, IL6, IL8, IL27, ICAM, VCAM-1, TNFa and VEGFA was higher in DME patients than in controls. In particular, median LCN2 concentration in diabetic patients was 5,711 pg/ml (interquartile range [IR] = 2,534), while in controls was 2,586 pg/ml (IR = 2,345). Moreover, median LCN2 was 6,534 pg/ml in the DME group (IR = 6,850) and 4,785 pg/ml in the PDR group (IR = 2,608), (p = 0.025).

conclusionVarious inflammatory and angiogenic factors are involved in the pathophysiology of PDR and DME. Elevated vitreous levels of LCN2 in PDR and especially in DME patients reveal a potential pathogenic association. More extended studies could verify LCN2 as an alternative therapeutic target.

Indexed as

Diabetes MellitusDiabetic RetinopathyInterleukin-27Lipocalin-2Macular EdemaAngiogenesis Inducing AgentsHumansInterleukin-6Interleukin-8Vascular Cell Adhesion Molecule-1Vitreous BodyAngiogenesis Inducing AgentsInterleukin-27Interleukin-6Interleukin-8LCN2 protein, humanLipocalin-2Vascular Cell Adhesion Molecule-1Angiogenic factorsDiabetic macula edemaInflammationLipocalin-2Vitreous

Identifiers

PMID36536319
PMCPMC9761947
OpenAlexW4313312730

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.