Evidence map›Paper›PMID 36536145›Full record

ArticleCardiovascular and interventional radiology2023

Role of Antiplatelet Therapy in Hemodialysis Arteriovenous Graft Secondary Patency Following Successful Percutaneous Thrombectomy.

Aaditya Nagaraj, Philip T Skummer, Vimal Gunasekaran, Christopher Johnson, Allan Roza, Dean Klinger, Sarah White, Amanda R Smolock

Open access · greenAbstract read
In one paragraph

Article in Cardiovascular and interventional radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Interpretable machine learning models for the prediction of all-cause mortality and time to death in hemodialysis patients.Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Aaditya NagarajRadiology Partners Houston, Medical Plaza 1, 902 Frostwood Dr., Ste 184, Houston, TX, 77024, USA.
Philip T SkummerDepartment of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Ave. Room 2803, Milwaukee, WI, 53226, USA.
Vimal GunasekaranMedical College of Wisconsin, Milwaukee, WI, USA.
Christopher JohnsonDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Allan RozaDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Dean KlingerDepartment of Surgery, Medical College of Wisconsin, Milwaukee, WI, USA.
Sarah WhiteDepartment of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Ave. Room 2803, Milwaukee, WI, 53226, USA.
Amanda R SmolockDepartment of Radiology, Division of Vascular and Interventional Radiology, Medical College of Wisconsin, 9200 W. Wisconsin Ave. Room 2803, Milwaukee, WI, 53226, USA. asmolock@mcw.edu.ORCID http://orcid.org/0000-0002-4173-7290
Medical College of Wisconsin · USPark Plaza Hospital · US

Funding

Clinical and Translational Science AwardUL1TR001436 · NCATS · MEDICAL COLLEGE OF WISCONSIN · PI FREED, JULIE K · 2015 to 2025
$47.5M
NCATS NIH HHS UL1 TR001436NCATS NIH HHS UL1TR001436
6 · The paper itself

Abstract

purposeThe purpose of this study was to elicit the relationship of antiplatelet therapy (AP) in maintaining arteriovenous graft (AVG) patency after successful percutaneous pharmacomechanical thrombectomy ("declot"). MATERIALS AND

methodsThis was an institutional review board-approved retrospective review of AVG declot procedures between July 2019 and August 2020. AVG characteristics, bleeding complications, anticoagulation and antiplatelet medication regimens, and thrombosis free survival were evaluated. Recurrent time-to-event analysis was performed using a Prentice-Williams-Peterson Gap time model was performed to evaluate AVG thrombosis free survival.

resultsA total of 109 declots were technically successful and performed in 63 individual patients. The majority of procedures were performed in upper arm grafts (71%, n = 45). Dual antiplatelet (DAPT) was prescribed after 52 declots (48%), single antiplatelet was prescribed after 36 declots (33%), and anticoagulation was prescribed after 31 declots (28%). Median thrombosis free survival was 37 days (range 1-412 days) in the no antiplatelet group, 84 days (range 1-427 days) in the single antiplatelet group, and 93 days (range 3-407 days) in the DAPT group. Anti-platelet medications trended towards protective of AVG thrombosis in multivariate analysis (hazard ratio 0.84, 95% confidence interval 0.60-1.19); however, this did not reach statistical significance (P = 0.33). A total of 4 major and 5 minor bleeding events occurred.

conclusionThe results of this study support further evaluation of AP therapy in preventing secondary rethrombosis of dialysis AVG.

Indexed as

Arteriovenous Shunt, SurgicalThrombosisAnticoagulantsGraft Occlusion, VascularHumansPlatelet Aggregation InhibitorsRenal DialysisRetrospective StudiesThrombectomyTreatment OutcomeVascular PatencyAnticoagulantsPlatelet Aggregation InhibitorsAntiplateletDeclotPatency

Identifiers

PMID36536145
PMCPMC10123846
OpenAlexW4312019143

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.