ArticleSurgical endoscopy2023
Diagnostic value of endoscopic ultrasonography for the depth of gastric cancer suspected of submucosal invasion: a multicenter prospective study.
Article in Surgical endoscopy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed.
- Analysis of clinicopathological characteristics of early gastric cancers with different endoscopic curability categories after endoscopic submucosal dissection and related risk factors of non-curative resection.Surgical endoscopy · 2026Article
- Improved diagnostic accuracy and safety of gel-endoscopic ultrasonography for deep submucosal invasion in early gastric cancer.Surgical endoscopy · 2026Article
- Combined multidetector computed tomography and gastrointestinal endoscopy for gastric cancer screening, preoperative staging, and lymph node metastasis detection.World journal of gastrointestinal oncology · 2026Article
- A combined approach using conventional endoscopy and endoscopic ultrasonography findings yields a highly accurate diagnosis of T2-muscularis propria gastric cancer.Clinical endoscopy · 2026Article
- The clinical value of endoscopic ultrasonography combined with endoscopic treatment for upper gastrointestinal lifting lesions.Frontiers in medicine · 2026Article
- Performance of an Artificial Intelligence Program for Assessing the Depth of Early Gastric Cancer Using Endoscopic Images.Endoscopy international open · 2026Article
- Risk factors and prediction model for submucosal invasion in early protruding-type esophagogastric junction adenocarcinoma: conventional endoscopy combines with endoscopic ultrasonography.BMC gastroenterology · 2025Article
- Endoscopic Ultrasound (EUS) in Gastric Cancer: Current Applications and Future Perspectives.Diseases (Basel, Switzerland) · 2025Review
- Development of a deep learning model for T1N0 gastric cancer diagnosis using 2.5D radiomic data in preoperative CT images.NPJ precision oncology · 2025Article
- Risk factors and predictive nomogram for non-curative resection in patients with early gastric cancer treated with endoscopic submucosal dissection: a retrospective cohort study.World journal of surgical oncology · 2025Article
- Endoscopic ultrasound classification for prediction of endoscopic submucosal dissection resectability: PREDICT classification.Endoscopy international open · 2024Article
- A novel artificial intelligence-based endoscopic ultrasonography diagnostic system for diagnosing the invasion depth of early gastric cancer.Journal of gastroenterology · 2024Article
- Applications and Prospects of Artificial Intelligence-Assisted Endoscopic Ultrasound in Digestive System Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Early Gastric Cancer: Update on Prevention, Diagnosis and Treatment.International journal of environmental research and public health · 2023Review
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20 authors.
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Abstract
backgroundAlthough the combination of conventional endoscopy (CE) and endoscopic ultrasonography (EUS) is useful for predicting the depth of early gastric cancer (EGC), the diagnostic value of EUS for submucosal (SM) invasive cancer has not been fully investigated.
methodsWe conducted a multicenter prospective study from May 2017 to January 2021 to evaluate the validity of a diagnostic strategy combining CE and EUS and to clarify the additional value of EUS for EGC suspected of SM invasion. In each case, the diagnosis was first made using CE, followed by EUS, and finally confirmed using a combination algorithm.
resultsA total of 180 patients with EGC were enrolled from 10 institutions, of which 175 were analyzed. The histopathological depths were M, SM1, SM2, and ≥ MP in 72, 16, 64, and 23 lesions, respectively. Treatment included 92 endoscopic submucosal dissection cases and 83 surgical cases. The overall diagnostic accuracy classified by M-SM1 or SM2-MP was 58.3% for CE, 75.7% for EUS, and 78.9% for the combination of CE and EUS; the latter two were significantly higher than that of CE alone (P < 0.001). The CE, EUS, and combination accuracy rates in 108 differentiated-type lesions were 51.9%, 77.4%, and 79.6%, respectively; the latter two were significantly higher than CE alone (P < 0.001). A significant additive effect of EUS was observed in CE-SM2 low-confidence lesions but not in CE-M-SM1 lesions or in CE-SM2 high-confidence lesions. Among the nine CE findings, irregular surface, submucosal tumor-like elevation, and non-extension signs were significant independent markers of pSM2-MP. Poorly delineated EUS lesions were misdiagnosed.
conclusionsEUS provides additional value for differentiated-type and CE-SM2 low-confidence EGCs in diagnosing invasion depth. CLINICAL REGISTRATION NUMBER: UMIN000025862.
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