Evidence map›Paper›PMID 36536017›Full record

ArticleScientific reports2022

Risk-aware survival time prediction from whole slide pathological images.

Zhixin Xu, Seohoon Lim, Hong-Kyu Shin, Kwang-Hyun Uhm, Yucheng Lu, Seung-Won Jung, Sung-Jea Ko

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In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhixin XuDepartment of Electrical Engineering, Korea University, Seongbuk-gu, Seoul, 02841, South Korea.
Seohoon LimDepartment of Electrical Engineering, Korea University, Seongbuk-gu, Seoul, 02841, South Korea.
Hong-Kyu ShinDepartment of Electrical Engineering, Korea University, Seongbuk-gu, Seoul, 02841, South Korea.
Kwang-Hyun UhmDepartment of Electrical Engineering, Korea University, Seongbuk-gu, Seoul, 02841, South Korea.
Yucheng LuEducation and Research Center for Socialware IT, Korea University, Seoul, 02841, South Korea.
Seung-Won JungDepartment of Electrical Engineering, Korea University, Seongbuk-gu, Seoul, 02841, South Korea. swjung83@korea.ac.kr.
Sung-Jea KoDepartment of Electrical Engineering, Korea University, Seongbuk-gu, Seoul, 02841, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deep-learning-based survival prediction can assist doctors by providing additional information for diagnosis by estimating the risk or time of death. The former focuses on ranking deaths among patients based on the Cox model, whereas the latter directly predicts the survival time of each patient. However, it is observed that survival time prediction for the patients, particularly with close observation times, possibly has incorrect orders, leading to low prediction accuracy. Therefore, in this paper, we present a whole slide image (WSI)-based survival time prediction method that takes advantage of both the risk as well as time prediction. Specifically, we propose to combine these two approaches by extracting the risk prediction features and using them as guides for the survival time prediction. Considering the high resolution of WSIs, we extract tumor patches from WSIs using a pre-trained tumor classifier and apply the graph convolutional network to aggregate information across these patches effectively. Extensive experiments demonstrate that the proposed method significantly improves the time prediction accuracy when compared with direct prediction of the survival times without guidance and outperforms existing methods.

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AwarenessPhysiciansHumansRecordsRisk Factors

Identifiers

PMID36536017
PMCPMC9763255

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.