ArticleScientific reports2022
Quantitative tissue perfusion imaging using nonlinear ultrasound localization microscopy.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- An ex vivo injury model perfused with whole blood reveals rapid mechanical and transcriptional changes within the spinal cord.Bioengineering & translational medicine · 2026Article
- Doppler Ultrasonography for Live Imaging and Quantification of Ovarian Vascular Function in Mice.Journal of visualized experiments : JoVE · 2025Article
- High-Volume Acquisition Rate Nonlinear Imaging Enables Robust 3-D Ultrasound Localization Microscopy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- OptimizingPhysics in medicine and biology · 2025Article
- Ultrasound super-resolution imaging for non-invasive assessment of microvessel in prostate lesion.Cancer imaging : the official publication of the International Cancer Imaging Society · 2025Article
- 3D ultrasound localization microscopy of the nonhuman primate brain.EBioMedicine · 2025Article
- Accuracy of 3D CE-MRA combined with ultrasound microbubble angiography for the diagnosis of lower extremity atherosclerotic occlusion.American journal of translational research · 2025Article
- Combining Super-Resolution Imaging and Shear Wave Elastography for Enhanced Risk Assessment of Moderate-to-Severe Renal Fibrosis in Chronic Kidney Disease Patients.International journal of nephrology and renovascular disease · 2025Article
- Article
- Contrast-Enhanced Ultrasound Imaging Detects Anatomical and Functional Changes in Rat Cervical Spine Microvasculature With Normal Aging.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Value of Ultrasound Super-Resolution Imaging for the Assessment of Renal Microcirculation in Patients with Acute Kidney Injury: A Preliminary Study.Diagnostics (Basel, Switzerland) · 2024Article
- Quantifying injury expansion in the cervical spinal cord with intravital ultrafast contrast-enhanced ultrasound imaging.Experimental neurology · 2024Article
- Contrast-enhanced ultrasound imaging detects anatomical and functional changes in rat cervical spine microvasculature with normal aging.bioRxiv : the preprint server for biology · 2024Article
- Contrast-Enhanced Ultrasound Demonstrates a Severity-Dependent Hemodynamic Response to Acute Dural Decompression in Contusive Rodent Spinal Cord Injury.Neurotrauma reportsArticle
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Ultrasound localization microscopy (ULM) is a recent advancement in ultrasound imaging that uses microbubble contrast agents to yield vascular images that break the classical diffraction limit on spatial resolution. Current approaches cannot image blood flow at the tissue perfusion level since they rely solely on differences in velocity to separate tissue and microbubble signals; lower velocity microbubble echoes are removed during high pass wall filtering. To visualize blood flow in the entire vascular tree, we have developed nonlinear ULM, which combines nonlinear pulsing sequences with plane-wave imaging to segment microbubble signals independent of their velocity. Bubble localization and inter-frame tracking produces super-resolved images and, with parameters derived from the bubble tracks, a rich quantitative feature set that can describe the relative quality of microcirculatory flow. Using the rat spinal cord as a model system, we showed that nonlinear ULM better resolves some smaller branching vasculature compared to conventional ULM. Following contusion injury, both gold-standard histological techniques and nonlinear ULM depicted reduced in-plane vessel length between the penumbra and contralateral gray matter (-16.7% vs. -20.5%, respectively). Here, we demonstrate that nonlinear ULM uniquely enables investigation and potential quantification of tissue perfusion, arguably the most important component of blood flow.
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