ArticleNPJ biofilms and microbiomes2022
The tongue biofilm metatranscriptome identifies metabolic pathways associated with the presence or absence of halitosis.
Article in NPJ biofilms and microbiomes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Dietary Sulfur Compounds and Halitosis: Bridging Food Science, Microbial Metabolism, and Oral Health: A Comprehensive Review.Molecular nutrition & food research · 2026Review
- Article
- [Research Progress on Microbiome-Driven Mechanisms and Intervention Strategies for Oral Malodor].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Review
- Effects of multiple tongue conditions on the diversity and composition of the oral microbiota.Journal of oral microbiology · 2026Article
- Probiotic intervention modulates volatile sulfur compound-associated pathways and oral microbiome balance in ligature-induced periodontitis rats.Journal of oral microbiology · 2026Article
- Article
- A comparison of oral microbiome composition between highly trained competitive athletes and untrained controls.Scientific reports · 2025Article
- Oral microbial signatures of head and neck cancer patients with diverse longitudinal oral mucositis severity patterns.bioRxiv : the preprint server for biology · 2025Article
- Nitrate supplementation affects taste by changing the oral metabolome and microbiome.NPJ biofilms and microbiomes · 2025Article
- hTAS2R38 polymorphisms modulate oral microbiota and influence the prevalence and treatment outcome of halitosis.Microbiome · 2025Article
- The blood pressure lowering effect of beetroot juice is impaired in periodontitis and recovered after periodontal treatment.NPJ biofilms and microbiomes · 2025Article
- Heat-KilledMicroorganisms · 2024Article
- The Effects of Nicotine Pouches and E-Cigarettes on Oral Microbes: A Pilot Study.Microorganisms · 2024Article
- Oral Health and Caries Prevention: How Tongue Hygiene Helps Maintain Balance of Microbiota and Overall Health in Pediatric Patients.Children (Basel, Switzerland) · 2024Review
- Oral nitrate-reducing bacteria as potential probiotics for blood pressure homeostasis.Frontiers in cardiovascular medicine · 2024Review
- Novel bacterial proteolytic and metabolic activity associated with dental erosion-induced oral dysbiosis.Microbiome · 2023Article
- Oral microbiome as a co-mediator of halitosis and periodontitis: a narrative review.Frontiers in oral health · 2023Review
- Reexamining the role ofGut microbesReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intra-oral halitosis usually results from the production of volatile sulfur compounds, such as methyl mercaptan and hydrogen sulfide, by the tongue microbiota. There are currently no reports on the microbial gene-expression profiles of the tongue microbiota in halitosis. In this study, we performed RNAseq of tongue coating samples from individuals with and without halitosis. The activity of Streptococcus (including S. parasanguinis), Veillonella (including V. dispar) and Rothia (including R. mucilaginosa) was associated with halitosis-free individuals while Prevotella (including P. shahi), Fusobacterium (including F. nucleatum) and Leptotrichia were associated with halitosis. Interestingly, the metatranscriptome of patients that only had halitosis levels of methyl mercaptan was similar to that of halitosis-free individuals. Finally, gene expression profiles showed a significant over-expression of genes involved in L-cysteine and L-homocysteine synthesis, as well as nitrate reduction genes, in halitosis-free individuals and an over-expression of genes responsible for cysteine degradation into hydrogen sulfide in halitosis patients.
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