Evidence map›Paper›PMID 36535906›Full record

ArticleJournal of clinical laboratory analysis2023

Post-COVID-19 fatal Aspergillus endocarditis: A case report.

Narges Najafi, Azam Moslemi, Rahman Ghafari, Shadi Shayesteh Azar, Maryam Nabati, Leila Faeli, Maryam Salimi, Roghayeh Mirzakhani, Tahereh Shokohi

Open access · goldAbstract readCase Reports
In one paragraph

Article in Journal of clinical laboratory analysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Journal of fungi (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Case reports in infectious diseases · 2025
    Article
  4. Post-COVID-19 fatal Aspergillus endocarditis: A case report.Journal of clinical laboratory analysis · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Narges NajafiDepartment of Infectious Diseases, Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Ghaemshahr, Iran.
Azam MoslemiStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.ORCID https://orcid.org/0000-0002-7324-7456
Rahman GhafariDepartment of Cardiac Surgery, Cardiovascular Research Center, Mazandaran Heart Center, Mazandaran University of Medical Sciences, Sari, Iran.
Shadi Shayesteh AzarDepartment of Infectious Diseases, Antimicrobial Resistance Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Ghaemshahr, Iran.
Maryam NabatiDepartment of Cardiology, Faculty of Medicine, Cardiovascular Research Center Mazandaran University of Medical Sciences, Sari, Iran.
Leila FaeliStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Maryam SalimiStudent Research Committee, Mazandaran University of Medical Sciences, Sari, Iran.
Roghayeh MirzakhaniMazandaran Heart Center, Mazandaran University of Medical Sciences, Sari, Iran.
Tahereh ShokohiInvasive Fungi Research Center, Communicable Diseases Institute, Mazandaran University of Medical Sciences, Sari, Iran.ORCID https://orcid.org/0000-0003-3094-8436
Mazandaran University of Medical Sciences · IR

Funding

Mazandaran University of Medical Sciences 1327
6 · The paper itself

Abstract

backgroundAspergillus endocarditis (AE) is a rare fatal infection. The infection is often reported in patients with prosthetic heart valves, immunosuppressed, broad-spectrum antimicrobial use regimens, and drug abusers.

methodsHerein, we report a rare case of native mitral valve AE in a 63-year-old man, with a probable COVID-19-associated invasive pulmonary aspergillosis nine months ago treated with antifungals.

resultsIn the last admission, the lethargy, neurological deficit, and septic-embolic brain abscess in brain MRI led to suspicion of infective endocarditis. Transesophageal two-dimensional echocardiography and color Doppler flow velocity mapping showed a large highly mobile mass destroying leaflet and severe mitral regurgitation. The Surgical valve replacement is performed. The surgical valve replacement is performed. Direct microscopic examination and culture of the explanted and vegetative mass revealed Aspergillus section Fumiagati confirmed by molecular method. Despite the administration of voriconazole and transient improvement the patient expired.

conclusionAs AE is a late consequence of COVID-19-associated invasive pulmonary aspergillosis, therefore, long-term follow-up of invasive aspergillosis, and prompt diagnosis of surgical and systemic antifungal therapy treatment, are warranted to provide robust management.

Indexed as

COVID-19EndocarditisInvasive Pulmonary AspergillosisAspergillusHumansMaleMiddle AgedVoriconazoleVoriconazoleAspergillus fumigatusCOVID-19endocarditisprosthetic heart valves

Identifiers

PMID36535906
PMCPMC9833957
OpenAlexW4311935800

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.