ArticleJornal de pediatria
Lactate acid level and prognosis of neonatal necrotizing enterocolitis: a retrospective cohort study based on pediatric-specific critical care database.
Article in Jornal de pediatria. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Analysis of Integrated Clinical, Laboratory and Prognostic Data of Neonates With Necrotizing Enterocolitis
Risk Factors for Poor Prognosis in Neonatal Necrotizing Enterocolitis
Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Lactate, mean platelet volume, and nSOFA as combined predictors of perforated necrotizing enterocolitis and mortality in preterm infants: a retrospective cohort study.Annals of medicine · 2026Article
- Lactate as a biomarker for discriminating and assessing prognosis of neonatal necrotising enterocolitis: A systematic review and meta-analysis.Pakistan journal of medical sciences · 2026Review
- Lactate combined with lymphocyte counts as useful predictors for the severity and prognosis of necrotizing enterocolitis: a retrospective cohort study.Annals of medicine · 2025Article
- Fulminant necrotizing enterocolitis: clinical features and a predictive model.BMC pediatrics · 2025Article
- Exploring the predictive value of pH in stratified mortality risk of NEC patients undergoing surgery: a retrospective study based on the PIC database.Translational pediatrics · 2025Article
- Diagnostic and Prognostic Value of Hematological Parameters in Necrotizing Enterocolitis: A Systematic Review.Journal of clinical medicine · 2025Review
- Lactate/albumin ratio as a prognostic biomarker for in-hospital mortality in pediatric patients with necrotizing enterocolitis.BMC pediatrics · 2025Article
- Does serum albumin at the onset of necrotisıng enterocolitis predict severe disease in preterm infants?Pediatric surgery international · 2024Article
- Surgery for intestinal injuries in very preterm infants: a Norwegian population-based study with a new approach to disease classification.BMJ paediatrics open · 2024Article
- New insights into intestinal macrophages in necrotizing enterocolitis: the multi-functional role and promising therapeutic application.Frontiers in immunology · 2023Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the relationship between lactate acid level and hospitalization mortality in neonatal necrotizing enterocolitis (NEC).
methodPaediatric-specific critical care database collected clinical data from the intensive care unit of Children's Hospital Affiliated to Zhejiang University Medical College from 2010 to 2018. Clinical and laboratory examination information of NEC patients was collected and divided into the death group and discharge group to find out the risk factors affecting the prognosis through univariate and multivariate analysis.
resultsAmong 104 NEC neonates, the admission age was 7.5 days and the weight was 2.03 kg. Comparing the death group with the discharge group, there were significant differences in therapeutic regimen, pH, serum albumin, total protein, creatinine and lactate acid. Multivariate and threshold effect analysis showed that lactate acid had a linear correlation with hospital mortality, and newborns who died in the hospital had much higher lactate levels than those who were discharged. The mortality of NEC newborns increased by 40-45% for every 1 mmol/L increase in lactate acid level.
conclusionsThere was a correlation between lactate acid level and hospital mortality in newborns with NEC, and lactate acid level was an important index to evaluate the prognosis of NEC.
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Registered trials
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