ArticleAnnals of internal medicine2023
Left Atrial Mechanical Dysfunction and the Risk for Ischemic Stroke in People Without Prevalent Atrial Fibrillation or Stroke : A Prospective Cohort Study.
Article in Annals of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07224178 (Left Atrial Strain), which is not on this map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Left Atrial Strain: A Biomarker for Cryptogenic Stroke Prevention
Who cites it
34 citing papers in PubMed, 48 citations in OpenAlex.
- Machine Learning-Derived Cardiovascular Aging Phenotypes From Cardiac Function and Stroke Risk in the UK Biobank: Cohort Study.JMIR aging · 2026Article
- The Thromboembolic Continuum in Transcatheter Mitral Valve Repair: A Comprehensive Review.Journal of clinical medicine · 2026Review
- RT-3DE TEE combined with 2D-STI to evaluate the correlation between left atrial and left auricular function and stroke in patients with non-valvular atrial fibrillation: a clinical investigation.BMC cardiovascular disorders · 2026Article
- Recent-onset atrial fibrillation: challenges and opportunities.European heart journal · 2026Review
- Metabolic Syndrome and Atrial Cardiomyopathy on the Risk of Stroke Mortality in the General Population.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Article
- Heart-brain axis pathophysiological understanding and clinical impact.Frontiers in cardiovascular medicine · 2026Review
- Atrial Cardiomyopathy: A "Distinct Clinical Entity" for a Deeper Understanding of Atrial Fibrillation and Cardioembolic Stroke.Journal of clinical medicine · 2025Review
- The predictive power of left atrial reservoir strain for long-term atrial fibrillation in the Atherosclerosis Risk in Communities study.Heart rhythm · 2025Article
- Associations of Midlife Leukocyte Telomere Length With Measures of Left Atrial Function in Community-Dwelling Older Adults: The ARIC Study.Journal of the American Heart Association · 2025Observational
- Association of Left Atrial Function With Mitral Regurgitation: The Atherosclerosis Risk in Communities Study.Journal of the American Heart Association · 2025Observational
- Time's imprint on the left atrium: aging and atrial myopathy.The journal of cardiovascular aging · 2025Article
- Greater Central Adiposity Is Associated With Poorer Left Atrial Function: The Atherosclerosis Risk in Communities (ARIC) Study.Mayo Clinic proceedings. Innovations, quality & outcomes · 2025Article
- Atrial Cardiomyopathy in Atrial Fibrillation: A Multimodal Diagnostic Framework.Diagnostics (Basel, Switzerland) · 2025Review
- Markers of Left Atrial Myopathy: Prognostic Usefulness for Ischemic Stroke and Dementia in People in Sinus Rhythm.Stroke · 2025Article
- Association of left atrial function with frailty: The Atherosclerosis Risk in Communities (ARIC) study.Journal of the American Geriatrics Society · 2024Article
- Overview and Future Direction of Embolic Stroke of Undetermined Source from the Insights of CHALLENGE ESUS/CS Registry.Journal of atherosclerosis and thrombosis · 2024Review
- Left atrial function during exercise stress echocardiography as a sign of paroxysmal/persistent atrial fibrillation.Cardiovascular ultrasound · 2024Article
- Prevalence of left atrial myopathy in people presenting for ablation of cavotricuspid isthmus-dependent right atrial flutter and the risk of developing atrial fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2024Article
- Patent Foramen Ovale and Other Cardiopathies as Causes of Embolic Stroke With Unknown Source.Journal of stroke · 2024Review
- Atrial cardiomyopathy revisited-evolution of a concept: a clinical consensus statement of the European Heart Rhythm Association (EHRA) of the ESC, the Heart Rhythm Society (HRS), the Asian Pacific Heart Rhythm Society (APHRS), and the Latin American Heart Rhythm Society (LAHRS).Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
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Authors and funding
12 authors at 8 institutions in 1 country.
Funding
Abstract
backgroundAtrial myopathy-characterized by changes in left atrial function and size-may precede and promote atrial fibrillation (AF) and cardiac thromboembolism. In people without prior AF or stroke, whether analysis of left atrial function and size can improve ischemic stroke prediction is unknown.
objectiveTo evaluate the association of echocardiographic left atrial function (reservoir, conduit, and contractile strain) and left atrial size (left atrial volume index) with ischemic stroke and determine whether these measures can improve the stroke prediction achieved by CHA
designProspective cohort study.
settingARIC (Atherosclerosis Risk in Communities) study.
participants4917 ARIC participants without prevalent stroke or AF. MEASUREMENTS: Ischemic stroke events (2011 to 2019) were adjudicated by physicians. Left atrial strain was measured using speckle-tracking echocardiography.
resultsOver 5 years, the cumulative incidences of ischemic stroke in the lowest quintiles of left atrial reservoir, conduit, and contractile strain were 2.99% (95% CI, 1.89% to 4.09%), 3.18% (CI, 2.14% to 4.22%), and 2.15% (CI, 1.09% to 3.21%), respectively, and that of severe left atrial enlargement was 1.99% (CI, 0.23% to 3.75%). On the basis of the Akaike information criterion, left atrial reservoir strain plus CHA LIMITATION: Underascertainment of subclinical AF.
conclusionIn people without prior AF or stroke, when added to CHA PRIMARY FUNDING SOURCE: National Heart, Lung, and Blood Institute of the National Institutes of Health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.