Evidence map›Paper›PMID 36534955›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2023

Cysteine-Selective Modification of Peptides and Proteins via Desulfurative C-C Bond Formation.

Rhys C Griffiths, Frances R Smith, Diyuan Li, Jasmine Wyatt, David M Rogers, Jed E Long, Lola M L Cusin, Patrick J Tighe, Robert Layfield, Jonathan D Hirst and 2 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. TiOACS nanoscience Au · 2026
    Article
  3. Article
  4. Peptide macrocyclisationChemical science · 2024
    Article
  5. Desulfurative Borylation of Small Molecules, Peptides, and Proteins.Journal of the American Chemical Society · 2023
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Rhys C GriffithsSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Frances R SmithSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.
Diyuan LiSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID http://orcid.org/0000-0002-0390-0448
Jasmine WyattDepartment of Chemistry, King's College London, London, SE1 1DB.
David M RogersSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID http://orcid.org/0000-0003-2167-113X
Jed E LongSchool of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.
Lola M L CusinSchool of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID http://orcid.org/0000-0002-1437-8034
Patrick J TigheSchool of Life Sciences, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID http://orcid.org/0000-0001-8326-093X
Robert LayfieldSchool of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.ORCID http://orcid.org/0000-0003-0702-3259
Jonathan D HirstSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID http://orcid.org/0000-0002-2726-0983
Manuel M MüllerDepartment of Chemistry, King's College London, London, SE1 1DB.ORCID http://orcid.org/0000-0001-6701-0893
Nicholas J MitchellSchool of Chemistry, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.ORCID http://orcid.org/0000-0002-9041-1852
University of Nottingham · GBKing's College London · GB

Funding

Wellcome Trust 202250/Z/16/Z
6 · The paper itself

Abstract

The site-selective modification of peptides and proteins facilitates the preparation of targeted therapeutic agents and tools to interrogate biochemical pathways. Among the numerous bioconjugation techniques developed to install groups of interest, those that generate C(sp

Indexed as

CysteineProteinsPeptidesCysteinePeptidesProteinsbioconjugationcysteinedesulfurizationpost-translational modificationssite-selective

Identifiers

PMID36534955
PMCPMC10946470
OpenAlexW4312018817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.