ArticleProceedings of the National Academy of Sciences of the United States of America2022
The squalene route to C30 carotenoid biosynthesis and the origins of carotenoid biosynthetic pathways.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 33 citations in OpenAlex.
- Microbe Profile:Microbiology (Reading, England) · 2026Review
- A Bacterial Natural Product Reshapes Phyllosphere Microbiome Composition by Blocking Carotenoid Biosynthesis.bioRxiv : the preprint server for biology · 2026Article
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- Pathway and efflux engineering to utilize endogenous high isoprenoid flux inApplied and environmental microbiology · 2026Article
- Three strains isolated from Northern Germany constitute the novel genera Njordella and Rania in the family Pirellulaceae.Scientific reports · 2026Article
- Tectonic setting shapes microbial biosynthetic potential across global geothermal environments.bioRxiv : the preprint server for biology · 2026Article
- Biophysical Characterization of a Carotenoprotein from Marine SpongeMarine drugs · 2026Article
- A novel strain isolated from methane seeps in the Kattegat belongs to the planctomycetal species Novipirellula methanifontis sp. nov.Scientific reports · 2026Article
- Substrate utilization and secondary metabolite biosynthesis in the phylum Planctomycetota.Applied microbiology and biotechnology · 2025Review
- Novel tools for genomic modification and heterologous gene expression in the phylum Planctomycetota.Applied microbiology and biotechnology · 2025Article
- A century of research on the Planctomycetota bacterial phylum, previously known as Planctomycetes.FEMS microbiology reviews · 2025Review
- Distribution of C30 carotenoid biosynthesis genes suggests habitat adaptation function in insect-adapted and nomadic Lactobacillaceae.Communications biology · 2024Article
- Comparative genomic analyses of aerobic planctomycetes isolated from the deep sea and the ocean surface.Antonie van Leeuwenhoek · 2024Article
- Carotenoid productivity in human intestinal bacteriaEngineering microbiology · 2024Article
- Planctoellipticum variicoloris gen. nov., sp. nov., a novel member of the family Planctomycetaceae isolated from wastewater of the aeration lagoon of a sugar processing plant in Northern Germany.Scientific reports · 2024Article
- A type III polyketide synthase cluster in the phylum Planctomycetota is involved in alkylresorcinol biosynthesis.Applied microbiology and biotechnology · 2024Article
- All Kinds of Sunny Colors Synthesized from Methane: Genome-Encoded Carotenoid Production byMicroorganisms · 2023Article
- Stratiformator vulcanicus gen. nov., sp. nov., a marine member of the family Planctomycetaceae isolated from a red biofilm in the Tyrrhenian Sea close to the volcanic island Panarea.Antonie van Leeuwenhoek · 2023Article
- Characterization of CSynthetic and systems biotechnology · 2023Article
- Anti-Inflammatory and Antioxidant Properties of Squalene in Copper Sulfate-Induced Inflammation in Zebrafish (International journal of molecular sciences · 2023Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Carotenoids are isoprenoid lipids found across the tree of life with important implications in oxidative stress adaptations, photosynthetic metabolisms, as well as in membrane dynamics. The canonical view is that C40 carotenoids are synthesized from phytoene and C30 carotenoids from diapophytoene. Squalene is mostly associated with the biosynthesis of polycyclic triterpenes, although there have been suggestions that it could also be involved in the biosynthesis of C30 carotenoids. However, demonstration of the existence of this pathway in nature is lacking. Here, we demonstrate that C30 carotenoids are synthesized from squalene in the Planctomycetes bacteria and that this squalene route to C30 carotenoids is the most widespread in prokaryotes. Using the evolutionary history of carotenoid and squalene amino oxidases, we propose an evolutionary scenario to explain the origin and diversification of the different carotenoid and squalene-related pathways. We show that carotenoid biosynthetic pathways have been constantly transferred and neofunctionalized during prokaryotic evolution. One possible origin of the squalene pathway connects it with the one of C40 carotenoid synthesis of Cyanobacteria. The widespread occurrence of the squalene route to C30 carotenoids in
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