ArticleProceedings of the National Academy of Sciences of the United States of America2022
Mesoscale structural gradients in human tooth enamel.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 30 citations in OpenAlex.
- Article
- Templateless crystallization of holococcolith crystals visualized by intracellular site-specific three-dimensional microscopy.PNAS nexus · 2026Article
- On the Observation of the Central Dark Line in the Human Tooth Enamel Crystals Through SEM, TEM, STEM, and AFM Microscopes.International journal of dentistry · 2026Article
- Elastic Energy Storage in Biological Materials: Internal Stresses and Their Functionality.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Review
- Therapeutic and protective effects of light-cured varnishes on erosive lesions: an in vitro study.BMC oral health · 2025Article
- Antimicrobial, remineralization, and infiltration: advanced strategies for interrupting dental caries.Medical review (2021) · 2025Review
- Mesoscale orchestration of collagen-based hierarchical mineralization.Nature communications · 2025Article
- Storage conditions differentially alter the human tooth enamel proteome.Frontiers in dental medicine · 2025Article
- Energy-dispersive Laue diffraction analysis of the influence of statherin and histatin on the crystallographic texture during human dental enamel demineralization.Journal of applied crystallography · 2024Article
- Adult dental epithelial stem cell-derived organoids deposit hydroxylapatite biomineral.International journal of oral science · 2023Article
- Multi-resolution Correlative Ultrastructural and Chemical Analysis of Carious Enamel by Scanning Microscopy and Tomographic Imaging.ACS applied materials & interfaces · 2023Article
- Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review.Dentistry journal · 2023Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The outstanding mechanical and chemical properties of dental enamel emerge from its complex hierarchical architecture. An accurate, detailed multiscale model of the structure and composition of enamel is important for understanding lesion formation in tooth decay (dental caries), enamel development (amelogenesis) and associated pathologies (e.g., amelogenesis imperfecta or molar hypomineralization), and minimally invasive dentistry. Although features at length scales smaller than 100 nm (individual crystallites) and greater than 50 µm (multiple rods) are well understood, competing field of view and sampling considerations have hindered exploration of mesoscale features, i.e., at the level of single enamel rods and the interrod enamel (1 to 10 µm). Here, we combine synchrotron X-ray diffraction at submicrometer resolution, analysis of crystallite orientation distribution, and unsupervised machine learning to show that crystallographic parameters differ between rod head and rod tail/interrod enamel. This variation strongly suggests that crystallites in different microarchitectural domains also differ in their composition. Thus, we use a dilute linear model to predict the concentrations of minority ions in hydroxylapatite (Mg
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Registered trials
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