Evidence map›Paper›PMID 36534758›Full record

ArticleBioconjugate chemistry2023

Semisynthesis of Aminomethyl-Insulin: An Atom-Economic Strategy to Increase the Affinity and Selectivity of a Protein for Recognition by a Synthetic Receptor.

Hayden R Anderson, Wei L Reeves, Andrew T Bockus, Paolo Suating, Amy G Grice, Madeleine Gallagher, Adam R Urbach

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioconjugate chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hayden R AndersonDepartment of Chemistry, Trinity University, San Antonio, Texas 78212, United States.
Wei L ReevesDepartment of Chemistry, Trinity University, San Antonio, Texas 78212, United States.
Andrew T BockusDepartment of Chemistry, Trinity University, San Antonio, Texas 78212, United States.
Paolo SuatingDepartment of Chemistry, Trinity University, San Antonio, Texas 78212, United States.ORCID 0000-0002-6030-1441
Amy G GriceDepartment of Chemistry, Trinity University, San Antonio, Texas 78212, United States.
Madeleine GallagherDepartment of Chemistry, Trinity University, San Antonio, Texas 78212, United States.
Adam R UrbachDepartment of Chemistry, Trinity University, San Antonio, Texas 78212, United States.ORCID 0000-0003-3426-4760
Trinity University · US

Funding

Minimal Protein Affinity TagsR15GM141708 · NIGMS · TRINITY UNIVERSITY · PI URBACH, ADAM ROBERT · 2021 to 2022
$528k
Supramolecular Strategies for the Controlled Release of Protein DrugsR15GM126511 · NIGMS · TRINITY UNIVERSITY · PI URBACH, ADAM ROBERT · 2017 to 2017
$400k
NIGMS NIH HHS R15 GM126511NIGMS NIH HHS R15 GM141708
6 · The paper itself

Abstract

Advancements in the molecular recognition of insulin by nonantibody-based means would facilitate the development of methodology for the continuous detection of insulin for the management of diabetes mellitus. Herein, we report a novel insulin derivative that binds to the synthetic receptor cucurbit[7]uril (Q7) at a single site and with high nanomolar affinity. The insulin derivative was prepared by a four-step protein semisynthetic method to present a 4-aminomethyl group on the side chain of the Phe

Indexed as

InsulinReceptors, ArtificialInsulinReceptors, Artificial

Identifiers

PMID36534758
PMCPMC10329871
OpenAlexW4311914142

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.