Evidence map›Paper›PMID 36534739›Full record

ReviewJMIR medical informatics2023

Ontologies Applied in Clinical Decision Support System Rules: Systematic Review.

Xia Jing, Hua Min, Yang Gong, Paul Biondich, David Robinson, Timothy Law, Christian Nohr, Arild Faxvaag, Lior Rennert, Nina Hubig and 1 more

Abstract readReview
In one paragraph

Review in JMIR medical informatics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Population health management of human phenotype ontology.Frontiers in artificial intelligence · 2025
    Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xia Jing *Department of Public Health Sciences, Clemson University, Clemson, SC, United States.ORCID https://orcid.org/0000-0002-1916-4588
Hua Min *College of Public Health, George Mason University, Fairfax, VA, United States.ORCID https://orcid.org/0000-0003-2422-0043
Yang Gong *School of Biomedical Informatics, The University of Texas Health Sciences Center at Houston, Houston, TX, United States.ORCID https://orcid.org/0000-0002-0864-8368
Paul BiondichClem McDonald Biomedical Informatics Center, Regenstrief Institute, Indianapolis, IN, United States.ORCID https://orcid.org/0000-0001-7637-1420
David RobinsonLoweswater Consulting, Combria, United Kingdom.ORCID https://orcid.org/0000-0002-2044-0754
Timothy LawOhio Musculoskeletal and Neurologic Institute, Ohio University, Athens, OH, United States.ORCID https://orcid.org/0000-0002-3899-072X
Christian NohrDepartment of Planning, Aalborg University, Aalborg, Denmark.ORCID https://orcid.org/0000-0003-1299-7365
Arild FaxvaagDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.ORCID https://orcid.org/0000-0002-6510-7306
Lior RennertDepartment of Public Health Sciences, Clemson University, Clemson, SC, United States.ORCID https://orcid.org/0000-0001-5275-7273
Nina HubigSchool of Computing, Clemson University, Clemson, SC, United States.ORCID https://orcid.org/0000-0002-8911-7832
Ronald GimbelDepartment of Public Health Sciences, Clemson University, Clemson, SC, United States.ORCID https://orcid.org/0000-0001-8185-4013

Funding

Tissue Structural and Neural Remodeling in Human Sacroiliac JointP20GM121342 · NIGMS · CLEMSON UNIVERSITY · PI Jeryl Jones · 2018 to 2026
$24.7M
Open, interoperable, and configurable clinical decision support modules for OpenMRS, OpenEMR, and beyondR01GM138589 · NIGMS · CLEMSON UNIVERSITY · PI JING, XIA · 2020 to 2024
$1.9M
NIGMS NIH HHS P20 GM121342NIGMS NIH HHS R01 GM138589
6 · The paper itself

Abstract

backgroundClinical decision support systems (CDSSs) are important for the quality and safety of health care delivery. Although CDSS rules guide CDSS behavior, they are not routinely shared and reused.

objectiveOntologies have the potential to promote the reuse of CDSS rules. Therefore, we systematically screened the literature to elaborate on the current status of ontologies applied in CDSS rules, such as rule management, which uses captured CDSS rule usage data and user feedback data to tailor CDSS services to be more accurate, and maintenance, which updates CDSS rules. Through this systematic literature review, we aim to identify the frontiers of ontologies used in CDSS rules.

methodsThe literature search was focused on the intersection of ontologies; clinical decision support; and rules in PubMed, the Association for Computing Machinery (ACM) Digital Library, and the Nursing & Allied Health Database. Grounded theory and PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) 2020 guidelines were followed. One author initiated the screening and literature review, while 2 authors validated the processes and results independently. The inclusion and exclusion criteria were developed and refined iteratively.

resultsCDSSs were primarily used to manage chronic conditions, alerts for medication prescriptions, reminders for immunizations and preventive services, diagnoses, and treatment recommendations among 81 included publications. The CDSS rules were presented in Semantic Web Rule Language, Jess, or Jena formats. Despite the fact that ontologies have been used to provide medical knowledge, CDSS rules, and terminologies, they have not been used in CDSS rule management or to facilitate the reuse of CDSS rules.

conclusionsOntologies have been used to organize and represent medical knowledge, controlled vocabularies, and the content of CDSS rules. So far, there has been little reuse of CDSS rules. More work is needed to improve the reusability and interoperability of CDSS rules. This review identified and described the ontologies that, despite their limitations, enable Semantic Web technologies and their applications in CDSS rules.

Indexed as

clinical decision support system rulesclinical decision support systemsinteroperabilityontologySemantic Web technology

Identifiers

PMID36534739
PMCPMC9896360

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.