Evidence map›Paper›PMID 36534652›Full record

ArticlePloS one2022

The regulation of a pigmentation gene in the formation of complex color patterns in Drosophila abdomens.

Komal K B Raja, Mujeeb O Shittu, Peter M E Nouhan, Tessa E Steenwinkel, Evan A Bachman, Prajakta P Kokate, Alexander McQueeney, Elizabeth A Mundell, Alexandri A Armentrout, Amber Nugent and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
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  4. RNAMethods and protocols · 2021
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  6. The Making of TransgenicMethods and protocols · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Komal K B RajaDepartment of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States of America.ORCID 0000-0001-7538-9805
Mujeeb O ShittuDepartment of Biotechnical and Clinical Laboratory Science, Jacobs School of Medicine and Biomedical Science, University at Buffalo, The State University of New York (SUNY), New York, United States of America.ORCID 0000-0002-7136-0308
Peter M E NouhanMcCourt School of Public Policy, Georgetown University, Washington, D.C., United States of America.
Tessa E SteenwinkelDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan, United States of America.ORCID 0000-0002-3949-930X
Evan A BachmanMichigan State University, College of Human Medicine, East Lansing, Michigan, United States of America.
Prajakta P KokateDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan, United States of America.
Alexander McQueeneySchool of Medicine, Eberhard Karls University of Tübingen, Geschwister-Scholl-Platz, Tübingen, Germany.
Elizabeth A MundellSchool of Technology, Michigan Technological University, Houghton, Michigan, United States of America.ORCID 0000-0002-2790-7492
Alexandri A ArmentroutDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan, United States of America.ORCID 0000-0001-6560-1489
Amber NugentDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan, United States of America.
Thomas WernerDepartment of Biological Sciences, Michigan Technological University, Houghton, Michigan, United States of America.ORCID 0000-0002-8865-365X
Michigan Technological University · USBaylor College of Medicine · USGeorgetown University · USMichigan United · USUniversity at Buffalo, State University of New York · USUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes in the control of developmental gene expression patterns have been implicated in the evolution of animal morphology. However, the genetic mechanisms underlying complex morphological traits remain largely unknown. Here we investigated the molecular mechanisms that induce the pigmentation gene yellow in a complex color pattern on the abdomen of Drosophila guttifera. We show that at least five developmental genes may collectively activate one cis-regulatory module of yellow in distinct spot rows and a dark shade to assemble the complete abdominal pigment pattern of Drosophila guttifera. One of these genes, wingless, may play a conserved role in the early phase of spot pattern development in several species of the quinaria group. Our findings shed light on the evolution of complex animal color patterns through modular changes of gene expression patterns.

Indexed as

DrosophilaDrosophila ProteinsAbdomenAnimalsEnhancer Elements, GeneticGene Expression Regulation, DevelopmentalPigmentationDrosophila Proteins

Identifiers

PMID36534652
PMCPMC9762589
OpenAlexW4311912002

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.