ArticleJournal of the American Chemical Society2023
Chiral Amplification through the Interplay of Racemizing Conditions and Asymmetric Crystal Growth.
Article in Journal of the American Chemical Society, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- Direct-inject liquid-chromatography enables an autonomous continuous preferential crystallization platform.Chemical science · 2026Article
- How Crystal Size and Number Steer Asymmetric Crystallization.The journal of physical chemistry letters · 2026Article
- Deracemization by coupling electrochemically assisted racemization and asymmetric crystallization.Chemical communications (Cambridge, England) · 2025Article
- Mechanistic Dissymmetry between Crystal Growth and Dissolution Drives Ratcheted Chiral Amplification.Journal of the American Chemical Society · 2025Article
- Strategies for chiral separation: from racemate to enantiomer.Chemical science · 2023Review
- Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor.Chemical communications (Cambridge, England) · 2023Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Amplification of enantiomeric excesses (ee) is routinely observed during chiral crystallization of conglomerate crystals for which the enantiomers undergo racemization in solution. Although routes comprising a combination of crystal growth and dissolution are frequently used to obtain enantiopure molecules, crystal growth by itself has rather been considered as a source of enantiomeric erosion and discounted as a potential source of enantiomeric amplification. Counterintuitively, we here demonstrate striking enantiomeric amplification during crystal growth for clopidogrel and
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.