Evidence map›Paper›PMID 36534598›Full record

ArticlePhysiological genomics2023

Echocardiography phenotyping in murine genetic reference population of BXD strains reveals significant QTLs associated with cardiac function and morphology.

Buyan-Ochir Orgil, Fuyi Xu, Undral Munkhsaikhan, Neely R Alberson, Akhilesh Kumar Bajpai, Jason N Johnson, Yao Sun, Jeffrey A Towbin, Lu Lu, Enkhsaikhan Purevjav

Open access · greenAbstract read
In one paragraph

Article in Physiological genomics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Molecular Pathways and Animal Models of Cardiomyopathies.Advances in experimental medicine and biology · 2024
    Article
  5. Article
  6. Expression Levels of theInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Buyan-Ochir OrgilDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Fuyi XuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
Undral MunkhsaikhanDepartment of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0002-7241-9172
Neely R AlbersonDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Akhilesh Kumar BajpaiDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
Jason N JohnsonDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Yao SunDivision of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.
Jeffrey A TowbinDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, Tennessee.
Enkhsaikhan PurevjavDepartment of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee.ORCID 0000-0001-6188-7176
University of Tennessee Health Science Center · USBinzhou Medical University · CNSt. Jude Children's Research Hospital · US

Funding

Discovery of modifier genes in cardiomyopathyR01HL151438 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, PUREVJAV, ENKHSAIKHAN · 2020 to 2023
$2.5M
Genetic Modulation of Hypertrophic Cardiomyopathy SeverityR01HL128350 · NHLBI · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI LU, LU, SUN, YAO · 2016 to 2019
$2.0M
NHLBI NIH HHS R01 HL128350NHLBI NIH HHS R01 HL151438
6 · The paper itself

Abstract

The genetic reference population of recombinant inbred BXD mice has been derived from crosses between C57BL/6J and DBA/2J strains. The DBA/2J parent exhibits cardiomyopathy phenotypes, whereas C57BL/6J has normal heart. BXD mice are sequenced for studying genetic interactions in cardiomyopathies. The study aimed to assess cardiomyopathy traits in BXDs and investigate the quantitative genetic architecture of those traits. Echocardiography, blood pressure, and cardiomyocyte size parameters obtained from 44 strains of BXD family (

Indexed as

EchocardiographyQuantitative Trait LociAnimalsCrosses, GeneticFemaleMaleMiceMice, Inbred C57BLMice, Inbred DBAMice, Inbred StrainsPhenotypeBXDcardiomyopathygenotype-phenotype associationQTLsystems genetics analysis

Identifiers

PMID36534598
PMCPMC9902221
OpenAlexW4311909650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.