ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2023
Differential regulation of sympathetic neural burst frequency and amplitude throughout normal pregnancy: a longitudinal study.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Insulin resistance is potentially associated with 24-h blood pressure variability related to blunted sympathetic reactivity in older adults with hypertension.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Temporal Dynamics of Catestatin Across Gestation: Links to Metabolic and Hemodynamic Adaptation.Life (Basel, Switzerland) · 2026Article
- Long-term microvascular and blood pressure dysregulation after Preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
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8 authors at 5 institutions in 3 countries.
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Abstract
Sympathetic activation is a hallmark of pregnancy. However, longitudinal assessments of muscle sympathetic nerve activity (MSNA) in pregnancy are scarce and have primarily focused on burst occurrence (frequency) at rest, despite burst strength (amplitude) representing distinct characteristics of sympathetic outflow. Thus, we assessed MSNA burst amplitude distributions in healthy women to determine the impact of normal pregnancy on neural discharge patterns in response to orthostatic stress. Twenty-six women were studied longitudinally during pre-, early- (4-8 wk of gestation), and late (32-36 wk) pregnancy, as well as postpartum (6-10 wk after delivery). MSNA, blood pressure (BP), and heart rate (HR) were measured in the supine posture and during graded head-up tilt (30° and 60° HUT). Mean and median MSNA burst amplitudes were used to characterize burst amplitude distribution. In late pregnancy, women demonstrated smaller increases in HR (
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