Evidence map›Paper›PMID 36534342›Full record

ArticleCell biology and toxicology2023

Oncoprotein SET dynamically regulates cellular stress response through nucleocytoplasmic transport in breast cancer.

Guomeng Zhao, Hongying Zhang, Yanchao Zhang, Na Zhao, Jinlei Mao, Pengzhao Shang, Kun Gao, Yao Meng, Yuhang Tao, Anlei Wang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Cell biology and toxicology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Guomeng Zhao *School of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Hongying Zhang *School of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Yanchao Zhang *School of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Na ZhaoSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Jinlei MaoSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Pengzhao ShangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Kun GaoSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Yao MengSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Yuhang TaoSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Anlei WangSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China.
Ziyi ChenHepatobiliary/Liver Transplantation Center, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People's Republic of China. dr_czy@126.com.
Changying GuoSchool of Life Science and Technology, China Pharmaceutical University, Nanjing, People's Republic of China. guocy74@gmail.com.
China Pharmaceutical University · CNJiangsu Province Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SETβ is the predominant isoform of oncoprotein SE translocation (SET) in various breast cancer cell lines. Interactome-transcriptome analysis has shown that SETβ is intimately associated with cellular stress response. Among various exogenous stimuli, formaldehyde (FA) causes distinct biological effects in a dose-dependent manner. In response to FA at different concentrations, SET dynamically shuttles between the nucleus and cytoplasm, performing diverse biofunctions to restore homeostasis. At a low concentration, FA acts as an epidermal growth factor (EGF) and activates the HER2 receptor and downstream signaling pathways in HER2

Indexed as

Breast NeoplasmsEpidermal Growth FactorActive Transport, Cell NucleusCell Line, TumorDNA HelicasesFemaleHumansOncogene ProteinsPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsDNA HelicasesEpidermal Growth FactorG3BP1 protein, humanOncogene ProteinsPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsFormaldehydeHER2p38αSETStress granule

Identifiers

PMID36534342
OpenAlexW4311932861

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.