SynthesisBiochemical genetics2023
Association Between IL10 Polymorphisms and the Susceptibility to Sepsis: A Meta-Analysis.
Synthesis in Biochemical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Genetic associations in sepsis and ARDS.Frontiers in pharmacology · 2026Review
- Observational
- The Interleukin Network in Sepsis: From Cytokine Storm to Clinical Applications.Diagnostics (Basel, Switzerland) · 2025Review
- Gene expression kinetics in Sepsis After Cardiac Surgery (SACS): a multicentric prospective observational study.Journal of anesthesia, analgesia and critical care · 2025Article
- The relationship between expression level and gene polymorphism of inflammatory factors and sepsis risk.Scientific reports · 2025Article
- Analysis of gene polymorphisms in patients with pulmonary infections based on next-generation sequencing technology and their prognostic predictive value.Frontiers in medicine · 2025Article
- The peptide genomic therapy increases antibacterial immunity and survival in sepsis by reprograming the gene orthologs of human immunodeficiencies in the spleen and lungs.Frontiers in immunology · 2025Article
- Article
- Single nucleotide polymorphisms in the development of osteomyelitis and prosthetic joint infection: a narrative review.Frontiers in immunology · 2024Review
- Immune Subtypes in Sepsis: A Retrospective Cohort Study Utilizing Clustering Methodology.Journal of inflammation research · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Many genetic variations have been identified to associate with sepsis in numerous studies, but the function of these variants in influencing sepsis is a complex process. We make use of mate-analysis and other analytic strategies (eQTL analysis and PPI network) to investigate the effect of interleukin-10 (IL10) on sepsis. Single-nucleotide polymorphisms (SNPs) in IL10 were analyzed in 3011 septic cases and 2976 controls from 22 studies. In results, the IL10-rs1800871 showed a significant association with sepsis in Asians (P < 0.05). Moreover, there is a association between rs1800896 and sepsis in pooled populations and Asians (P < 0.05). However, there is no association between rs1800872 and sepsis in different models. The three polymorphisms were also identified for the regulation of IL10 expression in an eQTL analyze, and the increased IL10 expression was related to the development of sepsis. Furthermore, the IL10 was discovered to associate with the expression of DRD1, TANK, MKL1, and STARD3NL genes in another independent cohort, which are functionally enriched for IRF3 (interferon regulatory factor 3)/IRF7 (interferon regulatory factor 7) and hormone pathways. In conclusion, the study confirmed the association between IL10 polymorphisms (rs1800871, rs1800872, rs1800896) and sepsis, and suggested the role of the variants in inflammatory pathologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.