ArticleJournal of neurology2023
Cerebellar alterations in Parkinson's disease with postural instability and gait disorders.
Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Dual-task gait training improves cognition and resting-state functional connectivity in Parkinson's disease with postural instability and gait disorders.Journal of neurology · 2024Trial
- Auditory cueing modulates motor performance and brain activity in early Parkinson's disease-a kinematic and fMRI study.NPJ Parkinson's disease · 2026Article
- Compensatory and Dynamic Cerebellar Responses to Striatal Lesions in Experimental Parkinsonism.Cerebellum (London, England) · 2026Article
- Breaking the Freeze: The Role of Cognitive Function in Freezing of Gait in Parkinson's Disease.Parkinson's disease · 2026Review
- Pathway Anchored Multimodal Clustering Reveals Circuit Level Signatures in Parkinsons Disease.bioRxiv : the preprint server for biology · 2025Article
- Unveiling hidden neurodegeneration in isolated REM sleep behavior disorder through MRI microstructure and glymphatic flow.NPJ Parkinson's disease · 2025Article
- Functional and Structural Connectivity Correlates of Axial Symptom Outcomes After Pallidal Deep Brain Stimulation in Parkinson's Disease.Brain sciences · 2025Article
- Cerebellar large-scale network connectivity in Parkinson's disease: associations with emotion, cognition, and aging effects.Brain imaging and behavior · 2025Article
- Cerebellar and extra-cerebellar symptoms in movement disorders.Arquivos de neuro-psiquiatria · 2025Review
- Neural and dopaminergic substrates of festinating gait in Parkinson's disease.Journal of neurology · 2025Article
- The alternation of neural oscillations during dual task standing in older adults with low back pain.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Reduced automaticity in freezing of gait is associated with elevated cortico-cerebellar connectivity.Brain imaging and behavior · 2025Article
- Patterns of cerebellar cortex hypermetabolism on motor and cognitive functions in PD.NPJ Parkinson's disease · 2025Article
- Cerebellum mitochondrial DNA copy number is increased in Parkinson's disease.Brain communications · 2025Article
- The Discovery of Phages in the Substantia Nigra and Its Implication for Parkinson's Disease.Research (Washington, D.C.) · 2025Article
- Effects of different magnetic stimulation paradigms on post-stroke upper limb function: a randomized controlled trial.Frontiers in neurology · 2025Article
- Five functional domains associated with gait performance in Parkinson's disease and lateral trunk flexion.Frontiers in neurology · 2025Article
- Gray Matter Asymmetry Alterations in Patients With Spinocerebellar Ataxia Type 3: A Voxel-Based Morphometric Comparison Study.CNS neuroscience & therapeutics · 2024Article
- Neural correlates of bradykinesia in Parkinson's disease: a kinematic and functional MRI study.NPJ Parkinson's disease · 2024Article
- Analysis of the Dynamics of Cognitive Impairments and Expression of Caspase Cascade Genes in Preclinical Stages of Parkinsonism Modeled Using α-Synuclein Oligomers.Bulletin of experimental biology and medicine · 2024Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies interrogated the involvement of cerebellum in modulating gait in Parkinson's disease (PD) patients with postural instability and gait disorders (PD-PIGD). This study aimed at assessing cerebellar atrophy and activity alterations during functional MRI (fMRI) gait-simulating motor- and dual-tasks in PD-PIGD.
methodsTwenty-one PD-PIGD and 23 healthy controls underwent clinical assessment, structural MRI, and fMRI including a motor-task (foot anti-phase movements) and a dual-task (foot anti-phase movements while counting backwards by threes). Grey matter cerebellar volumes were assessed using SUIT atlas. FMRI activations were extracted from each cerebellar lobule, and we correlated cerebellar and basal ganglia activity.
resultsPD-PIGD patients had reduced volumes of cerebellar motor and non-motor areas relative to controls. During fMRI motor-task, patients showed greater activation of cognitive cerebellar areas (VI and Crus I-II) vs controls. During fMRI dual-task, PD-PIGD patients showed increased activity of cognitive areas (Crus II) and reduced activity of motor areas (I-IV). Cerebellar structural alterations correlated with increased fMRI activity of cerebellar cognitive areas and with lower executive-attentive performance. The increased activity of Crus I during the motor-task correlated with a better motor performance in PD-PIGD. Moreover, the increased activity of cerebellum correlated with a reduced activity of putamen.
conclusionsIn PD-PIGD, the increased activity of non-motor cerebellar areas during gait-simulating tasks may be a consequence of grey matter atrophy or an attempt to compensate the functional failure of cerebellar motor areas and basal ganglia. Cerebellar MRI metrics are useful to characterize brain correlates of motor and dual-task abilities in PD-PIGD patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.