Evidence map›Paper›PMID 36533973›Full record

Trial reportExperimental physiology2023

The influence of alcohol on genioglossus single motor units in men and women during wakefulness.

Joanne Avraam, Andrew Dawson, Christian L Nicholas, Monika D Fridgant, Feiven Lee Fan, Amanda Kay, Zi Yi Koay, Rachel Greig, Fergal J O'Donoghue, John Trinder and 1 more

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental physiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Joanne AvraamMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Andrew DawsonMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Christian L NicholasMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Monika D FridgantMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Feiven Lee FanMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Amanda KayMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Zi Yi KoayMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Rachel GreigMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Fergal J O'DonoghueDepartment of Respiratory and Sleep Medicine and Institute for Breathing and Sleep, Austin Health, Heidelberg, Victoria, Australia.
John TrinderMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.
Amy S JordanMelbourne School of Psychological Sciences, University of Melbourne, Melbourne, Australia.ORCID 0000-0001-8561-9766
The University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

NEW

findingsWhat is the central question of this study? How does alcohol intake, which worsens obstructive sleep apnoea, alter motor control of the genioglossus muscle, an upper airway dilator, in healthy awake human volunteers, and does alcohol alter genioglossus muscle afterdischarge? What is the main finding and its importance? Alcohol consumption had a very minor effect on the activity of the genioglossus in healthy young individuals studied during wakefulness and did not alter afterdischarge, leaving open the possibility that alcohol worsens obstructive sleep apnoea via other mechanisms. ABSTRACT: Alcohol worsens obstructive sleep apnoea (OSA). This effect is thought to be due to alcohol's depressant effect on upper airway dilator muscles such as the genioglossus, but how alcohol reduces genioglossal activity is unknown. The aim of this study was to investigate the effect of alcohol consumption on genioglossus muscle single motor units (MUs). Sixteen healthy individuals were studied on two occasions (alcohol: breath alcohol concentration ∼0.07% and placebo). They were instrumented with a nasal mask, four intramuscular genioglossal EMG electrodes, and an ear oximeter. They were exposed to 8-12 hypoxia trials (45-60 s of 10% O

Indexed as

Sleep Apnea, ObstructiveWakefulnessElectromyographyFacial MusclesFemaleHumansHypoxiaMaleTracheaethanolobstructive sleep apnoeapharyngeal musclessnoringupper airway

Identifiers

PMID36533973
PMCPMC10103883
OpenAlexW4311928631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.