Evidence map›Paper›PMID 36533936›Full record

ArticleAngewandte Chemie (International ed. in English)2023

Protoglobin-Catalyzed Formation of cis-Trifluoromethyl-Substituted Cyclopropanes by Carbene Transfer.

Lucas Schaus, Anuvab Das, Anders M Knight, Gonzalo Jimenez-Osés, K N Houk, Marc Garcia-Borràs, Frances H Arnold, Xiongyi Huang

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Harnessing Photoenzymatic Systems for Intermolecular C-H Fluorination.Angewandte Chemie (International ed. in English) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Enzymatic Stereodivergent Synthesis of Azaspiro[2.y]alkanes.Journal of the American Chemical Society · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Biocatalytic Synthesis of α-Amino Esters via Nitrene C-H Insertion.Journal of the American Chemical Society · 2024
    Article
  13. Article
  14. Stereospecific Enzymatic Conversion of Boronic Acids to Amines.Journal of the American Chemical Society · 2024
    Article
  15. Article
  16. Article
  17. Enzymatic Nitrogen Incorporation Using Hydroxylamine.Journal of the American Chemical Society · 2023
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lucas SchausDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125, USA.
Anuvab DasDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125, USA.ORCID 0000-0002-9344-4414
Anders M KnightDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125, USA.ORCID 0000-0001-9665-8197
Gonzalo Jimenez-OsésCenter for Cooperative Research in Biosciences (CIC bioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160, Derio, Spain.ORCID 0000-0003-0105-4337
K N HoukDepartment of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0002-8387-5261
Marc Garcia-BorràsInstitut de Química Computacional i Catàlisi and Departament de Química, Universitat de Girona, C/M. Aurèlia Capmany, 69, 17003, Girona, Spain.ORCID 0000-0001-9458-1114
Frances H ArnoldDivision of Chemistry and Chemical Engineering, California Institute of Technology, 1200 E California Blvd., Pasadena, CA 91125, USA.
Xiongyi HuangDepartment of Chemistry, Johns-Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-7156-8881

Funding

Expanding the chemistry of life: New enzymatic platforms for synthesis of bioactive organofluorinesR00GM129419 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI HUANG, XIONGYI · 2020 to 2022
$747k
NIGMS NIH HHS R00 GM129419
6 · The paper itself

Abstract

Trifluoromethyl-substituted cyclopropanes (CF

Indexed as

CyclopropanesMethaneCatalysisStereoisomerismcarbeneCyclopropanesMethaneBiocatalysisCarbenesCyclopropanesOrganofluorinesProtoglobins

Identifiers

PMID36533936
PMCPMC9894577

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.