Evidence map›Paper›PMID 36533917›Full record

ArticleInfection and immunity2023

Helicobacter pylori Chronic-Stage Inflammation Undergoes Fluctuations That Are Altered in

Kevin S Johnson, Christina Yang, J Elliot Carter, Atesh K Worthington, Elektra K Robinson, Raymond Lopez-Magaña, Frida Salgado, Isabelle Arnold, Karen M Ottemann

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Kevin S JohnsonDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Christina YangDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
J Elliot CarterDepartment of Pathology, University of South Alabama College of Medicine, Mobile, Alabama, USA.
Atesh K WorthingtonDepartment of Molecular, Cellular, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, USA.
Elektra K RobinsonDepartment of Molecular, Cellular, and Developmental Biology, University of California Santa Cruz, Santa Cruz, California, USA.
Raymond Lopez-MagañaDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Frida SalgadoDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.
Isabelle ArnoldInstitute of Experimental Immunology, University of Zürich, Zürich, Switzerland.
Karen M OttemannDepartment of Microbiology and Environmental Toxicology, University of California Santa Cruz, Santa Cruz, California, USA.ORCID 0000-0001-6265-7401
University of California, Santa Cruz · USUniversity of South Alabama · USUniversity of Zurich · CH

Funding

The function of chemotactic signal transduction during colonization and diseaseR01AI116946 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI OTTEMANN, KAREN M · 2016 to 2025
$5.1M
NIAID NIH HHS R01 AI116946
6 · The paper itself

Abstract

Helicobacter pylori colonizes half of the world's population and is responsible for a significant disease burden by causing gastritis, peptic ulcers, and gastric cancer. The development of host inflammation drives these diseases, but there are still open questions in the field about how H. pylori controls this process. We characterized H. pylori inflammation using an 8-month mouse infection time course and comparison of the wild type (WT) and a previously identified mutant lacking the TlpA chemoreceptor that causes elevated inflammation. Our work shows that H. pylori chronic-stage corpus inflammation undergoes surprising fluctuations, with changes in Th17 and eosinophil numbers. The H. pylori

Indexed as

GastritisHelicobacter InfectionsHelicobacter pyloriAnimalsBacterial ProteinsChemotaxisGastric MucosaInflammationMiceBacterial Proteinschemoreceptorschemotaxischronic infectiongastricgut inflammation

Identifiers

PMID36533917
PMCPMC9872690
OpenAlexW4311933456

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.