ArticleMagnetic resonance in medicine2023
Optimization of 4D combined angiography and perfusion using radial imaging and arterial spin labeling.
Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Concurrent Four-Dimensional Dynamic MRA and Perfusion Imaging Using Dual-Module Arterial Spin Labeling MRI With Stack-Of-Stars Golden-Angle Radial Acquisition.NMR in biomedicine · 2026Article
- Combined angiography and perfusion using radial imaging and arterial spin labeling with structural contrast.Magnetic resonance in medicine · 2026Article
- Dynamic pseudo-continuous arterial spin labeling angiography using a 3D-radial multi-spoke spoiled gradient-recalled sequence.Magnetic resonance in medicine · 2026Article
- Ultra-high temporal resolution 4D angiography using arterial spin labeling with subspace reconstruction.Magnetic resonance in medicine · 2025Article
- Efficient 3D cone trajectory design for improved combined angiographic and perfusion imaging using arterial spin labeling.Magnetic resonance in medicine · 2024Article
- Cervical spinal cord angiography and vessel-selective perfusion imaging in the rat.NMR in biomedicine · 2024Article
- Optimization of 4D combined angiography and perfusion using radial imaging and arterial spin labeling.Magnetic resonance in medicine · 2023Article
- Time-encoded pseudo-continuous arterial spin labeling: Increasing SNR in ASL dynamic angiography.Magnetic resonance in medicine · 2023Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo extend and optimize a non-contrast MRI technique to obtain whole head 4D (time-resolved 3D) qualitative angiographic and perfusion images from a single scan.
methods4D combined angiography and perfusion using radial imaging and arterial spin labeling (CAPRIA) uses pseudocontinuous labeling with a 3D golden ratio ("koosh ball") readout to continuously image the blood water as it travels through the arterial system and exchanges into the tissue. High spatial/temporal resolution angiograms and low spatial/temporal resolution perfusion images can be flexibly reconstructed from the same raw k-space data. Constant and variable flip angle (CFA and VFA, respectively) excitation schedules were optimized through simulations and tested in healthy volunteers. A conventional sensitivity encoding (SENSE) reconstruction was compared against a locally low rank (LLR) reconstruction, which leverages spatiotemporal correlations. Comparison was also made with time-matched time-of-flight angiography and multi-delay EPI perfusion images. Differences in image quality were assessed through split-scan repeatability.
resultsThe optimized VFA schedule (2-9°) resulted in a significant (p < 0.001) improvement in image quality (up to 84% vs. CFA), particularly for the lower SNR perfusion images. The LLR reconstruction provided effective denoising without biasing the signal timecourses, significantly improving angiographic and perfusion image quality and repeatability (up to 143%, p < 0.001). 4D CAPRIA performed well compared with time-of-flight angiography and had better perfusion signal repeatability than the EPI-based approach (p < 0.001).
conclusion4D CAPRIA optimized using a VFA schedule and LLR reconstruction can yield high quality whole head 4D angiograms and perfusion images from a single scan.
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