Evidence map›Paper›PMID 36533844›Full record

ReviewGlia2023

Movers and shakers: Microglial dynamics and modulation of neural networks.

Brendan Steven Whitelaw, Mark Blohm Stoessel, Ania Katarzyna Majewska

Abstract readReview
In one paragraph

Review in Glia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. ER and SOCE CaCell calcium · 2024
    Article
  12. Review
  13. Article
  14. Article
  15. ER and SOCE CabioRxiv : the preprint server for biology · 2024
    Article
  16. Review
  17. Cortical microglia dynamics are conserved during voluntary wheel running.Journal of applied physiology (Bethesda, Md. : 1985) · 2024
    Article
  18. Synapse Regulation.Advances in neurobiology · 2024
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brendan Steven WhitelawDepartment of Neuroscience, Center for Visual Science, University of Rochester, Rochester, New York, USA.ORCID 0000-0001-5552-1506
Mark Blohm StoesselDepartment of Neuroscience, Center for Visual Science, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-7785-2645
Ania Katarzyna MajewskaDepartment of Neuroscience, Center for Visual Science, University of Rochester, Rochester, New York, USA.ORCID 0000-0002-2167-6849

Funding

VISUAL INDICES OF NEUROTOXICITYP30ES001247 · NIEHS · UNIVERSITY OF ROCHESTER · PI B Paige Lawrence · 1985 to 2026
$42.8M
Dynamic neuroimmune interactions in the onset and progression of FASDR01AA027111 · NIAAA · UNIV OF ARKANSAS FOR MED SCIS · PI DREW, PAUL D, MAJEWSKA, ANNA K · 2018 to 2022
$2.3M
Mechanisms that regulate microglial dynamics in the context of plasticity (Supplement)R01NS114480 · NINDS · UNIVERSITY OF ROCHESTER · PI MAJEWSKA, ANNA K · 2020 to 2024
$2.2M
The role of PI3Kg signaling in microglial dynamics and experience dependent synaptic plasticityF30MH120974 · NIMH · UNIVERSITY OF ROCHESTER · PI WHITELAW, BRENDAN STEVEN · 2019 to 2022
$198k
Dynamics of and Function Cerebellar MicrogliaF31NS120609 · NINDS · UNIVERSITY OF ROCHESTER · PI STOESSEL, MARK BLOHM · 2020 to 2022
$138k
NIAAA NIH HHS R01 AA027111NIEHS NIH HHS P30 ES001247NIMH NIH HHS F30 MH120974NINDS NIH HHS F31 NS120609NINDS NIH HHS R01 NS114480
6 · The paper itself

Abstract

Microglia are multifaceted cells that act as immune sentinels, with important roles in pathological events, but also as integral contributors to the normal development and function of neural circuits. In the last decade, our understanding of the contributions these cells make to synaptic health and dysfunction has expanded at a dizzying pace. Here we review the known mechanisms that govern the dynamics of microglia allowing these motile cells to interact with synapses, and recruit microglia to specific sites on neurons. We then review the molecular signals that may underlie the function of microglia in synaptic remodeling. The emerging picture from the literature suggests that microglia are highly sensitive cells, reacting to neuronal signals with dynamic and specific actions tuned to the need of specific synapses and networks.

Indexed as

MicrogliaSynapsesNerve NetNeural Networks, ComputerNeuronal PlasticityNeuronsmicrogliasignaling pathwayssynaptic plasticity

Identifiers

PMID36533844
PMCPMC10729610

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.