ArticleThe plant genome2023
Brown midrib mutant and genome-wide association analysis uncover lignin genes for disease resistance in maize.
Article in The plant genome, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- From Defense Executor to Engineering Target: Harnessing Lignin for Crop Resistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- A MaERF110-MaMYB308 Transcriptional Module Negatively Regulates Lignin-Mediated Defence Against Fusarium Wilt in Banana.Plant biotechnology journal · 2026Article
- Physiological and biochemical markers associated with root lignification and micronutrient uptake in wheat genotypes with contrasting resistance to Gaeumannomyces tritici.Scientific reports · 2026Article
- Insights into the genetic and biochemical basis of Gibberella ear rot resistance in maize.The plant genome · 2025Article
- Designing a nitrogen-efficient cold-tolerant maize for modern agricultural systems.The Plant cell · 2025Review
- Cellulose synthase TaCESA7 negatively regulates wheat resistance to stripe rust by reducing cell wall lignification.Stress biology · 2025Article
- Comparative transcriptome analysis reveals potential regulatory genes involved in the development and strength formation of maize stalks.BMC plant biology · 2025Article
- Genome-Wide Association Study of Cuticle and Lipid Droplet Properties of Cucumber (International journal of molecular sciences · 2024Article
- Genome-wide identification of theFrontiers in plant science · 2024Article
- Brown midrib mutant and genome-wide association analysis uncover lignin genes for disease resistance in maize.The plant genome · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brown midrib (BMR) maize (Zea mays L.) harbors mutations that result in lower lignin levels and higher feed digestibility, making it a desirable silage market class for ruminant nutrition. Northern leaf blight (NLB) epidemics in upstate New York highlighted the disease susceptibility of commercially grown BMR maize hybrids. We found the bm1, bm2, bm3, and bm4 mutants in a W64A genetic background to be more susceptible to foliar fungal (NLB, gray leaf spot [GLS], and anthracnose leaf blight [ALB]) and bacterial (Stewart's wilt) diseases. The bm1, bm2, and bm3 mutants showed enhanced susceptibility to anthracnose stalk rot (ASR), and the bm1 and bm3 mutants were more susceptible to Gibberella ear rot (GER). Colocalization of quantitative trait loci (QTL) and correlations between stalk strength and disease traits in recombinant inbred line families suggest possible pleiotropies. The role of lignin in plant defense was explored using high-resolution, genome-wide association analysis for resistance to NLB in the Goodman diversity panel. Association analysis identified 100 single and clustered single-nucleotide polymorphism (SNP) associations for resistance to NLB but did not implicate natural functional variation at bm1-bm5. Strong associations implicated a suite of diverse candidate genes including lignin-related genes such as a β-glucosidase gene cluster, hct11, knox1, knox2, zim36, lbd35, CASP-like protein 8, and xat3. The candidate genes are targets for breeding quantitative resistance to NLB in maize for use in silage and nonsilage purposes.
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