ArticleJournal of the American Heart Association2022
Nitrites, Nitrates, and Cardiovascular Outcomes: Are We Living "La Vie en Rose" With Pink Processed Meats?
Article in Journal of the American Heart Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.
- Global research landscape and emerging frontiers of ultra-processed food intake and cardiometabolic health: a bibliometric and knowledge-mapping analysis (2015-2025).Frontiers in nutrition · 2026Pooled it
- Association between red meat consumption and risk of stroke: a meta-analysis of prospective cohort studies.Frontiers in nutrition · 2026Pooled it
- Review
- Associations between preservative food additives and type 2 diabetes incidence in the NutriNet-Santé prospective cohort.Nature communications · 2026Article
- Food additive mixtures in French children and adults: the nationally representative Esteban study.Scientific reports · 2025Article
- Prospective association between dietary source-determined nitrate/nitrite and the risk of metabolic syndrome among children and adolescents: Tehran lipid and glucose study.Nutrition journal · 2025Article
- Health impacts of exposure to synthetic chemicals in food.Nature medicine · 2025Review
- Red Meat Consumption and Hypertension: An Updated Review.Current cardiology reports · 2025Review
- A systematic analysis of the global disease burden of type 2 diabetes mellitus attributable to high intake of processed meat in 204 countries (1990-2021).Frontiers in endocrinology · 2025Article
- Ultra-Processed Food Consumption and Risk of Incident Hypertension in US Middle-Aged Adults.Journal of the American Heart Association · 2024Article
- Ultra-processed foods and cardiometabolic health: public health policies to reduce consumption cannot wait.BMJ (Clinical research ed.) · 2023Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Background Nitrates and nitrites are used as food additives in processed meats. They are also commonly ingested from water and several foods. Several short-term clinical studies suggested beneficial effects of dietary nitrates on blood pressure, while deleterious effects on oxidative damage have been suggested in some experimental studies. However, there is a lack of evidence from longitudinal epidemiological studies linking foods and water-originated and additives-originated nitrites and nitrates, separately, to hypertension and cardiovascular diseases risk. We aimed to study these associations in a large population-based cohort. Methods and Results Overall, 106 288 adults from the French NutriNet-Santé cohort (2009-2022) were included. Associations between nitrites and nitrates intakes and hypertension and cardiovascular disease risks were assessed using multi-adjusted Cox proportional hazard models. During follow-up, 3810 incident cases of hypertension and 2075 cases of cardiovascular diseases were ascertained. Participants with higher intakes of additives-originated nitrites (sodium nitrite in particular [European code e250]) had a higher hypertension risk compared with nonconsumers (hazard ratio, 1.19 [95% CI, 1.08-1.32],
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.