Evidence map›Paper›PMID 36533346›Full record

ArticleBeijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2022

[Role of hyperglycemia-induced 5-hydroxytryptamine degradation of hepatic stellate cells in hepatic inflammation and fibrosis induced by type 2 diabetes mellitus].

X R Liang, X C Shan, J Guan, R Zhang, J Yang, Y Zhang, J Q Jin, Y X Zhang, F Xu, J H Fu

Open access · greenAbstract readEnglish Abstract
PubMed Full text at PMC
In one paragraph

Article in Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Desloratadine as the selective 5HTJournal of neuroinflammation · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

X R LiangCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
X C ShanCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
J GuanCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
R ZhangCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
J YangCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Y ZhangCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
J Q JinCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
Y X ZhangCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
F XuCollege of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
J H FuDepartment of Physiology, College of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210009, China.
China Pharmaceutical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo explore the role of 5-hydroxytryptamine (5-HT) in type 2 diabetes mellitus (T2DM)-related hepatic inflammation and fibrosis.

methodsMale C57BL/6J mice were used to establish T2DM model by high-fat diet feeding combined with intraperitoneal injection of streptozotocin. Then, the mice with hyperglycemia were still fed with high-fat diet for nine weeks, and treated with or without 5-HT

resultsThere were up-regulated expressions of 5-HT

conclusionHyperglycemia-induced myofibroblastization and TGF-β1 production of HSCs, which leads to hepatic inflammation and fibrosis in T2DM mice, is probably due to the up-regulation of 5-HT

Indexed as

Diabetes Mellitus, Type 2HyperglycemiaAnimalsGlucoseHepatic Stellate CellsHumansHydrogen PeroxideInflammationLiver CirrhosisMaleMiceMice, Inbred C57BLMonoamine OxidaseReactive Oxygen SpeciesSerotoninTransforming Growth Factor beta1GlucoseHydrogen PeroxideMonoamine OxidaseReactive Oxygen SpeciesSerotoninTransforming Growth Factor beta15-hydroxytryptamineHepatic fibrosisHepatic stellate cellsInflammationReactive oxygen species

Identifiers

PMID36533346
PMCPMC9761804
OpenAlexW4312066564

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.