Evidence map›Paper›PMID 36533218›Full record

ArticleVeterinary and animal science2023

Determining the association between gut microbiota and its metabolites with higher intestinal Immunoglobulin A response.

Mrigendra Rajput, Tooba Momin, Amit Singh, Surya Banerjee, Andrew Villasenor, Jessica Sheldon, Pratikshya Paudel, Ravindra Rajput

Open access · goldAbstract read
In one paragraph

Article in Veterinary and animal science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Modulatory Effects ofNutrients · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. High-value valorization ofFrontiers in veterinary science · 2025
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Fructose malabsorption in ChREBP-deficient mice disrupts the small intestine immune microenvironment and leads to diarrhea-dominant bowel habit changes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Mrigendra RajputDepartment of Biology, University of Dayton, Dayton, OH, 45469, United States of America.
Tooba MominDepartment of Biology, University of Dayton, Dayton, OH, 45469, United States of America.
Amit SinghDepartment of Biology, University of Dayton, Dayton, OH, 45469, United States of America.
Surya BanerjeeDepartment of Biological Sciences, Arkansas Tech University Russellville, AR, 72801, United States of America.
Andrew VillasenorDepartment of Biology, University of Dayton, Dayton, OH, 45469, United States of America.
Jessica SheldonDepartment of Biology, University of Dayton, Dayton, OH, 45469, United States of America.
Pratikshya PaudelDepartment of Biological Sciences, Arkansas Tech University Russellville, AR, 72801, United States of America.
Ravindra RajputDepartment of Mathematics, Statistics and Computer Science, G. B. Pant University of Agriculture and Technology, Pantnagar, 263145, India.
University of Dayton · USArkansas Tech University · USGovind Ballabh Pant University of Agriculture and Technology · IN

Funding

Understanding Hesitant AdoptersP20GM103429 · NIGMS · UNIV OF ARKANSAS FOR MED SCIS · PI Lawrence E Cornett, JERRY WARE · 2012 to 2026
$60.9M
Genetic Basis of Dorso-Ventral Patterning in the Drosophila EyeR01EY032959 · NEI · UNIVERSITY OF DAYTON · PI KANGO-SINGH, MADHURI, SINGH, AMIT · 2021 to 2025
$2.2M
NEI NIH HHS R01 EY032959NIGMS NIH HHS P20 GM103429
6 · The paper itself

Abstract

Immunoglobulin A (IgA) is one of the important and most abundant immunoglobulins which neutralize invading pathogens at mucosal sites. Gut microbial community and their metabolites which are responsible for higher IgA are poorly known. The current study was carried out to determine those microbial community and their metabolites. Twenty-two healthy, 26 days wean piglets were used in the study. After 10 days of weaning, piglets were divided into two groups. Group 1 with significantly higher fecal IgA while group 2 with significantly lower IgA concentrations from each other. Both groups were analyzed for the fecal inflammatory cytokine, fecal microbial community using 16S ribosomal sequencing, and microbial metabolites using GC-MS. Results showed that Firmicutes and Bacteroidetes constituted 90.56% of the microbiome population in the fecal matter of pigs with higher IgA concentration while pigs with lower fecal IgA had Firmicutes and Bacteroidetes abundance as of 95.56%. Pigs with higher IgA had significantly higher Bacteroidota and Desulfobacterota populations, while significantly lower Firmicutes and Firmicutes/ Bacteroidota ratio (

Indexed as

Bacterial metabolitesGut immune systemGut microbiotaimmunoglobulin A (IgA)

Identifiers

PMID36533218
PMCPMC9755367
OpenAlexW4311766511

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.