Evidence map›Paper›PMID 36533148›Full record

ArticleVirus evolution2022

Intrahost evolution of the HIV-2 capsid correlates with progression to AIDS.

M T Boswell, J Nazziwa, K Kuroki, A Palm, S Karlson, F Månsson, A Biague, Z J da Silva, C O Onyango, T I de Silva and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virus evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

M T BoswellNuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK.
J NazziwaDepartment of Translational Medicine, Lund University, Sölvegatan 17, 223 62, Lund, Sweden.
K KurokiFaculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
A PalmDepartment of Translational Medicine, Lund University, Sölvegatan 17, 223 62, Lund, Sweden.
S KarlsonDepartment of Translational Medicine, Lund University, Sölvegatan 17, 223 62, Lund, Sweden.
F MånssonDepartment of Translational Medicine, Lund University, Sölvegatan 17, 223 62, Lund, Sweden.
A BiagueNational Public Health Laboratory, V94M+HM4, Bissau, Guinea-Bissau.
Z J da SilvaNational Public Health Laboratory, V94M+HM4, Bissau, Guinea-Bissau.
C O OnyangoUS Centres for Disease Control, KEMRI Complex, Mbagathi Road off Mbagathi Way PO Box 606-00621, Kenya.
T I de SilvaDepartment of Infection, Immunity and Cardiovascular Disease, The Medical School, University of Sheffield, Beech Hill Rd, S10 2RX, Sheffield, UK.
A JayeMedical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Atlantic Boulevard, Fajara P. O. Box 273, Banjul, The Gambia.
H NorrgrenDepartment of Clinical Sciences Lund, Lund University, Sölvegatan 19, 221 84 Lund, Sweden.
P MedstrandDepartment of Translational Medicine, Lund University, Sölvegatan 17, 223 62, Lund, Sweden.
M JanssonDepartment of Laboratory Medicine, Lund University, Sölvegatan 19, Sweden.
K MaenakaFaculty of Pharmaceutical Sciences and Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Kita-12, Nishi-6, Kita-ku, Sapporo 060-0812, Japan.
S L Rowland-JonesNuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK.
J EsbjörnssonNuffield Department of Medicine, University of Oxford, Roosevelt Drive, OX3 7FZ, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-2 infection will progress to AIDS in most patients without treatment, albeit at approximately half the rate of HIV-1 infection. HIV-2 capsid (p26) amino acid polymorphisms are associated with lower viral loads and enhanced processing of T cell epitopes, which may lead to protective Gag-specific T cell responses common in slower progressors. Lower virus evolutionary rates, and positive selection on conserved residues in HIV-2

Indexed as

capsidevolutionHIV-2p26

Identifiers

PMID36533148
PMCPMC9753047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.