Evidence map›Paper›PMID 36533081›Full record

ArticleFrontiers in molecular biosciences2022

2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in

Emily Schifano, Giorgia Conta, Adele Preziosi, Carino Ferrante, Giovanni Batignani, Patrizia Mancini, Alberta Tomassini, Fabio Sciubba, Tullio Scopigno, Daniela Uccelletti and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Non-invasive treatment ofFrontiers in microbiology · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Nutrients · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Emily SchifanoDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Rome, Italy.
Giorgia ContaDepartment of Environmental Biology, Sapienza University of Rome, Rome, Italy.
Adele PreziosiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Rome, Italy.
Carino FerranteDepartment of Physics, Sapienza University of Rome, Rome, Italy.
Giovanni BatignaniDepartment of Physics, Sapienza University of Rome, Rome, Italy.
Patrizia ManciniDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Alberta TomassiniDepartment of Environmental Biology, Sapienza University of Rome, Rome, Italy.
Fabio SciubbaDepartment of Environmental Biology, Sapienza University of Rome, Rome, Italy.
Tullio ScopignoDepartment of Physics, Sapienza University of Rome, Rome, Italy.
Daniela UccellettiDepartment of Biology and Biotechnology "C. Darwin", Sapienza University of Rome, Rome, Italy.
Alfredo MiccheliDepartment of Environmental Biology, Sapienza University of Rome, Rome, Italy.
Sapienza University of Rome · ITItalian Institute of Technology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High levels of 2-hydroxyisobutyric acid (2-HIBA) were found in urines of patients with obesity and hepatic steatosis, suggesting a potential involvement of this metabolite in clinical conditions. The gut microbial origin of 2-HIBA was hypothesized, however its actual origin and role in biological processes are still not clear. We investigated how treatment with 2-HIBA affected the physiology of the model organism

Indexed as

2-hydroxyisobutyric acidageingCaenorhabditis elegansCARShigh-glucose dietlipid metabolismmetabolomicsoxidative stress

Identifiers

PMID36533081
PMCPMC9749906
OpenAlexW4309700977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.