Evidence map›Paper›PMID 36532747›Full record

ArticleFrontiers in pharmacology2022

The botanical drug PBI-05204, a supercritical CO

Sara Vaccaro, Alessandra Rossetti, Antonella Porrazzo, Simona Camero, Matteo Cassandri, Silvia Pomella, Miriam Tomaciello, Giampiero Macioce, Francesca Pedini, Giovanni Barillari and 15 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 12 institutions in 2 countries.

Sara VaccaroDepartment of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Alessandra RossettiDepartment of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L'Aquila, L'Aquila, Italy.
Antonella PorrazzoDepartment of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Simona CameroDepartment of Maternal, Infantile and Urological Sciences, "Sapienza" University of Rome, Rome, Italy.
Matteo CassandriDepartment of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Silvia PomellaDepartment of Oncohematology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Miriam TomacielloDepartment of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Giampiero MacioceDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Francesca PediniDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Giovanni BarillariDepartment of Clinical Sciences and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.
Cinzia MarcheseDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
Rossella RotaDepartment of Oncohematology, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.
Giovanni CenciDipartimento Biologia e Biotecnologie "C. Darwin," "Sapienza" University of Rome, Rome, Italy.
Mario TomboliniOtolaryngology Department, San Giovanni-Addolorata Hospital, Rome, Italy.
Robert A NewmanPhoenix Biotechnology Inc., San Antonio, TX, United States.
Peiying YangDepartment of Palliative, Rehabilitation and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Silvia CodenottiDepartment of Molecular and Translational Medicine, Division of Biotechnology, University of Brescia, Brescia, Italy.
Alessandro FanzaniDepartment of Molecular and Translational Medicine, Division of Biotechnology, University of Brescia, Brescia, Italy.
Francesca MegiorniDepartment of Experimental Medicine, "Sapienza" University of Rome, Rome, Italy.
Claudio FestucciaDepartment of Biotechnological and Applied Clinical Sciences, Laboratory of Radiobiology, University of L'Aquila, L'Aquila, Italy.
Giuseppe MinnitiRadiation Oncology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
Giovanni Luca GravinaDepartment of Biotechnological and Applied Clinical Sciences, Radiotherapy Oncology Unit, St Salvatore Hospital, University of L'Aquila, L'Aquila, Italy.
Francesca VulcanoDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Luisa MilazzoDepartment of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy.
Francesco MaramponDepartment of Radiotherapy, Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Istituto Superiore di Sanità · ITSapienza University of Rome · ITBambino Gesù Children's Hospital · ITUniversity of L'Aquila · ITUniversity of Brescia · ITAzienda Ospedaliera San Giovanni Addolorata · ITIstituto Neurologico Mediterraneo · ITIstituto Pasteur · ITPhoenix (United States) · USPoliclinico Umberto I · ITThe University of Texas MD Anderson Cancer Center · USUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Treatment of rhabdomyosarcoma (RMS), the most common a soft tissue sarcoma in childhood, provides intensive multimodal therapy, with radiotherapy (RT) playing a critical role for local tumor control. However, since RMS efficiently activates mechanisms of resistance to therapies, despite improvements, the prognosis remains still largely unsatisfactory, mainly in RMS expressing chimeric oncoproteins PAX3/PAX7-FOXO1, and fusion-positive (FP)-RMS. Cardiac glycosides (CGs), plant-derived steroid-like compounds with a selective inhibitory activity of the Na

Indexed as

Na/K +ATPaseoleandrinPBI-05204radiosenisitizing agentradiotherapyrhabdomyosarcoma

Identifiers

PMID36532747
PMCPMC9751381
OpenAlexW4311047872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.