Evidence map›Paper›PMID 36532708›Full record

ArticleFaculty reviews2022

A genetic roadmap to the response to genotoxic agents in human cells.

Alberto Ciccia, Roger A Greenberg, Susan P Lees-Miller, Andre Nussenzweig

Open access · diamondAbstract readComment
In one paragraph

Article in Faculty reviews, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Alberto CicciaColumbia University Irving Medical Center.ORCID https://orcid.org/0000-0003-4789-6564
Roger A GreenbergUniversity of Pennsylvania.ORCID https://orcid.org/0000-0003-1326-8981
Susan P Lees-MillerUniversity of Calgary.ORCID https://orcid.org/0000-0001-5809-2516
Andre NussenzweigNational Institutes of Health.ORCID https://orcid.org/0000-0003-0037-7898
California University of Pennsylvania · USColumbia University Irving Medical Center · USNational Institutes of Health · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To maintain genome fidelity and prevent diseases such as cancer, our cells must constantly detect, and efficiently and precisely repair, DNA damage. Paradoxically, DNA-damaging agents in the form of radiation and chemotherapy are also used to treat cancer. Olivieri

Indexed as

CRISPRDNA damageDNA-damaging agentsDNA repair

Identifiers

PMID36532708
PMCPMC9721265
OpenAlexW4312065570

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.